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• W2016996903 abstract "Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies." @default.
• W2016996903 created "2016-06-24" @default.
• W2016996903 creator A5021611700 @default.
• W2016996903 creator A5024511512 @default.
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• W2016996903 creator A5039422521 @default.
• W2016996903 creator A5080924048 @default.
• W2016996903 creator A5083236827 @default.
• W2016996903 date "2015-03-01" @default.
• W2016996903 modified "2023-10-15" @default.
• W2016996903 title "Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy" @default.
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