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• W2016996930 abstract "Summary 1. Liver mitochondria behave as cation-exchangers which are surrounded by semipermeable membranes. The apparent K m 's of binding are: H + , 10 −6.6 M; Ca 2+ , 4·10 −5 M; Mg 2+ , 2·10 −3 M; K + , 10 −1 M; K + , in presence of valinomycin, 5·10 −3 M. 2. Substances which alter the permeability of mitochondrial membranes also alter the apparent binding affinities of the mitochondria for various cations, and facilitate exchanges of the cations, especially exchanges between H + and other cations. 3. These exchanges can lead to the apparent alkalination or acidification of the interior of the mitochondria. 4. The role of substrate is to produce H + inside mitochondria. These protons can leave intact mitochondria only by exchanging with some cation. 5. Addition of divalent anions, which diffuse slowly into mitochondria, leads to removal of cations from mitochondria. 6. Substances which cause a loss of bound cations from mitochondria, also lead to an increased rate of oxygen utilization. Likewise, addition of cations at a concentration sufficient to promote cation exchanges on the mitochondrial anionic sites result in increased utilization of oxygen. 7. These data imply that the energetic mechanism of both oxidative phosphorylation and cation transport are the same process, and both reactions are driven by the ability of mitochondria to separate charge (H + and OH − ) 8 . It is proposed that this separation of charge results in alkalination of the interior of the mitochondria, and this alkalination leads either to intramitochondrial precipitation of divalent cation phosphate salts, in the presence of large amounts of divalent cations and Pi in the buffer, or to dehydration of the ATP synthetase sites by removal of OH − from the enzyme by precipitation of the OH − , as Mg(OH) 2 . The dehydrated ATP synthetase enzyme is capable of exchanging its high energy bond via coupling factors with P i and finally of transferring this dehydrated enzyme-bound P i to ADP." @default.
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• W2016996930 date "1965-01-01" @default.
• W2016996930 modified "2023-10-11" @default.
• W2016996930 title "Cation exchange and oxidative phosphorylation in mitochondria" @default.
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• W2016996930 doi "https://doi.org/10.1016/s0926-6593(65)80059-5" @default.
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