Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017001601> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2017001601 endingPage "540" @default.
- W2017001601 startingPage "535" @default.
- W2017001601 abstract "Angiotensin II (Ang II) binding sites were characterized in primary cultures of bovine brain microvessel endothelial cell (BMEC) monolayers. Binding of [3H]Ang II to BMECs was time dependent and saturable. Scatchard plot analysis of dose-dependent [3H]Ang II binding revealed a single population of binding sites (Kd=3.1 nM, Bmax=52 fmoles/mg protein). Sarathrin, an Ang II antagonist, and saralasin, a partial agonist, inhibited [3H]Ang II binding to BMEC monolayers, whereas two unrelated peptides, bradykinin and arginine-vasopressin, had no effect on the specific binding of [3H]Ang II. At 37°C, [3H]Ang II was internalized in BMECs and this uptake appeared to be saturable. Nanomolar concentrations of Ang II and saralasin stimulated [3H]thymidine uptake in serum-free starved BMEC monolayers, corresponding to an increase in DNA synthesis. On the other hand, sarathrin had no effect on [3H]thymidine uptake. The affinity of the single population of Ang II of binding sites was consistent with the concentration range of Ang II actions demonstrated in several cell types including BMECs. The Ang II-mediated actions on DNA synthesis suggest that this peptide-hormone may possess growth regulating properties in BMECs through either surface or internal site interactions. Collective findings support the complex nature of Ang II in regulating vascular and nonvascular cell growth and permeability characteristics." @default.
- W2017001601 created "2016-06-24" @default.
- W2017001601 creator A5053073841 @default.
- W2017001601 creator A5062574786 @default.
- W2017001601 date "1991-05-01" @default.
- W2017001601 modified "2023-09-23" @default.
- W2017001601 title "Some characteristics of specific angiotensin II binding sites on bovine brain microvessel endothelial cell monolayers" @default.
- W2017001601 cites W1575840121 @default.
- W2017001601 cites W1821554906 @default.
- W2017001601 cites W1947330935 @default.
- W2017001601 cites W1969071707 @default.
- W2017001601 cites W1981194894 @default.
- W2017001601 cites W1986402630 @default.
- W2017001601 cites W1995894492 @default.
- W2017001601 cites W2013166832 @default.
- W2017001601 cites W2023968060 @default.
- W2017001601 cites W2025812362 @default.
- W2017001601 cites W2029348336 @default.
- W2017001601 cites W2031032144 @default.
- W2017001601 cites W2046061254 @default.
- W2017001601 cites W2053043994 @default.
- W2017001601 cites W2062228467 @default.
- W2017001601 cites W2064327485 @default.
- W2017001601 cites W2065914370 @default.
- W2017001601 cites W2075865306 @default.
- W2017001601 cites W2087364210 @default.
- W2017001601 cites W2092171289 @default.
- W2017001601 cites W2106902261 @default.
- W2017001601 cites W2110675963 @default.
- W2017001601 cites W2158210173 @default.
- W2017001601 cites W2404852681 @default.
- W2017001601 cites W4232326783 @default.
- W2017001601 cites W4293247451 @default.
- W2017001601 cites W59744083 @default.
- W2017001601 doi "https://doi.org/10.1016/0196-9781(91)90097-9" @default.
- W2017001601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1923932" @default.
- W2017001601 hasPublicationYear "1991" @default.
- W2017001601 type Work @default.
- W2017001601 sameAs 2017001601 @default.
- W2017001601 citedByCount "14" @default.
- W2017001601 countsByYear W20170016012021 @default.
- W2017001601 crossrefType "journal-article" @default.
- W2017001601 hasAuthorship W2017001601A5053073841 @default.
- W2017001601 hasAuthorship W2017001601A5062574786 @default.
- W2017001601 hasConcept C104849204 @default.
- W2017001601 hasConcept C107824862 @default.
- W2017001601 hasConcept C123012128 @default.
- W2017001601 hasConcept C126322002 @default.
- W2017001601 hasConcept C134018914 @default.
- W2017001601 hasConcept C170493617 @default.
- W2017001601 hasConcept C185592680 @default.
- W2017001601 hasConcept C202751555 @default.
- W2017001601 hasConcept C2776370428 @default.
- W2017001601 hasConcept C2776823063 @default.
- W2017001601 hasConcept C2908647359 @default.
- W2017001601 hasConcept C2908929049 @default.
- W2017001601 hasConcept C55493867 @default.
- W2017001601 hasConcept C71924100 @default.
- W2017001601 hasConcept C86803240 @default.
- W2017001601 hasConcept C99454951 @default.
- W2017001601 hasConceptScore W2017001601C104849204 @default.
- W2017001601 hasConceptScore W2017001601C107824862 @default.
- W2017001601 hasConceptScore W2017001601C123012128 @default.
- W2017001601 hasConceptScore W2017001601C126322002 @default.
- W2017001601 hasConceptScore W2017001601C134018914 @default.
- W2017001601 hasConceptScore W2017001601C170493617 @default.
- W2017001601 hasConceptScore W2017001601C185592680 @default.
- W2017001601 hasConceptScore W2017001601C202751555 @default.
- W2017001601 hasConceptScore W2017001601C2776370428 @default.
- W2017001601 hasConceptScore W2017001601C2776823063 @default.
- W2017001601 hasConceptScore W2017001601C2908647359 @default.
- W2017001601 hasConceptScore W2017001601C2908929049 @default.
- W2017001601 hasConceptScore W2017001601C55493867 @default.
- W2017001601 hasConceptScore W2017001601C71924100 @default.
- W2017001601 hasConceptScore W2017001601C86803240 @default.
- W2017001601 hasConceptScore W2017001601C99454951 @default.
- W2017001601 hasIssue "3" @default.
- W2017001601 hasLocation W20170016011 @default.
- W2017001601 hasLocation W20170016012 @default.
- W2017001601 hasOpenAccess W2017001601 @default.
- W2017001601 hasPrimaryLocation W20170016011 @default.
- W2017001601 hasRelatedWork W1966583389 @default.
- W2017001601 hasRelatedWork W1971613811 @default.
- W2017001601 hasRelatedWork W1994154819 @default.
- W2017001601 hasRelatedWork W1996846474 @default.
- W2017001601 hasRelatedWork W1998631290 @default.
- W2017001601 hasRelatedWork W2047925791 @default.
- W2017001601 hasRelatedWork W2069855804 @default.
- W2017001601 hasRelatedWork W2092349071 @default.
- W2017001601 hasRelatedWork W2137237120 @default.
- W2017001601 hasRelatedWork W1996764561 @default.
- W2017001601 hasVolume "12" @default.
- W2017001601 isParatext "false" @default.
- W2017001601 isRetracted "false" @default.
- W2017001601 magId "2017001601" @default.
- W2017001601 workType "article" @default.