Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017001937> ?p ?o ?g. }
- W2017001937 endingPage "86" @default.
- W2017001937 startingPage "81" @default.
- W2017001937 abstract "Nuclear Factor (NF)-κB and Focal Adhesion Kinase (FAK) signalling are implicated in cardiomyocyte hypertrophy. We investigated whether FAK signalling contributed towards NF-κB activation by mechanical stress in cardiac myocytes. Experiments were performed with pressure overload rat left ventricle and isolated cardiac myocytes from adult rats and isolated neonatal rat ventricular myocytes (NRVMs) underwent in vitro stretching. Pressure overload induced NF-κB increase in myocardial cell nuclear extracts. Adult rat isolated cardiac myocyte confocal microscopy analysis showed NF-κB detected into nuclei. Cyclic stretch increased the amount and NF-κB DNA-binding activity in NRVMs nuclear extracts. NRVMs confocal microscopy confirmed NF-κB subcelullar relocation in stretched cells. Changes in NF-κB subcelular location and DNA-binding activity in stretched NRVMs were paralleled by increased FAK phosphorylation, detected in stretched NRVMs by anti-phosphospecific antibody directed to Tyr397. NRVMs treatment with FAK/Src pharmacological inhibitor attenuated NF-κB subcelullar relocation and increased DNA binding activity induced by cyclic stretch in cardiac myocytes. FAK signalling coordinates cardiac myocyte NF-κB activation in response to mechanical stress. Further studies are needed to elucidate the influence of this signalling pathway on gene transcription regulation, and cardiac myocyte phenotypic changes in response to mechanical stress." @default.
- W2017001937 created "2016-06-24" @default.
- W2017001937 creator A5010221629 @default.
- W2017001937 creator A5018050724 @default.
- W2017001937 creator A5082674717 @default.
- W2017001937 date "2009-05-01" @default.
- W2017001937 modified "2023-09-30" @default.
- W2017001937 title "FAK signalling mediates NF-κB activation by mechanical stress in cardiac myocytes" @default.
- W2017001937 cites W1971006006 @default.
- W2017001937 cites W1975334457 @default.
- W2017001937 cites W1975866732 @default.
- W2017001937 cites W1988036810 @default.
- W2017001937 cites W1988651446 @default.
- W2017001937 cites W1995380251 @default.
- W2017001937 cites W2002806885 @default.
- W2017001937 cites W2006834821 @default.
- W2017001937 cites W2014252953 @default.
- W2017001937 cites W2024581871 @default.
- W2017001937 cites W2039198415 @default.
- W2017001937 cites W2048202123 @default.
- W2017001937 cites W2053383702 @default.
- W2017001937 cites W2059983531 @default.
- W2017001937 cites W2065491098 @default.
- W2017001937 cites W2065611313 @default.
- W2017001937 cites W2071141743 @default.
- W2017001937 cites W2090363054 @default.
- W2017001937 cites W2095644154 @default.
- W2017001937 cites W2102389608 @default.
- W2017001937 cites W2112203191 @default.
- W2017001937 cites W2115157006 @default.
- W2017001937 cites W2116193546 @default.
- W2017001937 cites W2131577319 @default.
- W2017001937 cites W2135624975 @default.
- W2017001937 cites W2137477023 @default.
- W2017001937 cites W2158070304 @default.
- W2017001937 cites W2159026236 @default.
- W2017001937 cites W2166046639 @default.
- W2017001937 cites W2166781034 @default.
- W2017001937 doi "https://doi.org/10.1016/j.cca.2009.01.023" @default.
- W2017001937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19361463" @default.
- W2017001937 hasPublicationYear "2009" @default.
- W2017001937 type Work @default.
- W2017001937 sameAs 2017001937 @default.
- W2017001937 citedByCount "26" @default.
- W2017001937 countsByYear W20170019372014 @default.
- W2017001937 countsByYear W20170019372015 @default.
- W2017001937 countsByYear W20170019372016 @default.
- W2017001937 countsByYear W20170019372017 @default.
- W2017001937 countsByYear W20170019372019 @default.
- W2017001937 countsByYear W20170019372020 @default.
- W2017001937 countsByYear W20170019372021 @default.
- W2017001937 countsByYear W20170019372022 @default.
- W2017001937 countsByYear W20170019372023 @default.
- W2017001937 crossrefType "journal-article" @default.
- W2017001937 hasAuthorship W2017001937A5010221629 @default.
- W2017001937 hasAuthorship W2017001937A5018050724 @default.
- W2017001937 hasAuthorship W2017001937A5082674717 @default.
- W2017001937 hasConcept C11960822 @default.
- W2017001937 hasConcept C134018914 @default.
- W2017001937 hasConcept C151166631 @default.
- W2017001937 hasConcept C153911025 @default.
- W2017001937 hasConcept C167414201 @default.
- W2017001937 hasConcept C185592680 @default.
- W2017001937 hasConcept C207200792 @default.
- W2017001937 hasConcept C2777730290 @default.
- W2017001937 hasConcept C2778271984 @default.
- W2017001937 hasConcept C2779178360 @default.
- W2017001937 hasConcept C3018686881 @default.
- W2017001937 hasConcept C3018791406 @default.
- W2017001937 hasConcept C62478195 @default.
- W2017001937 hasConcept C86803240 @default.
- W2017001937 hasConcept C95444343 @default.
- W2017001937 hasConceptScore W2017001937C11960822 @default.
- W2017001937 hasConceptScore W2017001937C134018914 @default.
- W2017001937 hasConceptScore W2017001937C151166631 @default.
- W2017001937 hasConceptScore W2017001937C153911025 @default.
- W2017001937 hasConceptScore W2017001937C167414201 @default.
- W2017001937 hasConceptScore W2017001937C185592680 @default.
- W2017001937 hasConceptScore W2017001937C207200792 @default.
- W2017001937 hasConceptScore W2017001937C2777730290 @default.
- W2017001937 hasConceptScore W2017001937C2778271984 @default.
- W2017001937 hasConceptScore W2017001937C2779178360 @default.
- W2017001937 hasConceptScore W2017001937C3018686881 @default.
- W2017001937 hasConceptScore W2017001937C3018791406 @default.
- W2017001937 hasConceptScore W2017001937C62478195 @default.
- W2017001937 hasConceptScore W2017001937C86803240 @default.
- W2017001937 hasConceptScore W2017001937C95444343 @default.
- W2017001937 hasIssue "1-2" @default.
- W2017001937 hasLocation W20170019371 @default.
- W2017001937 hasLocation W20170019372 @default.
- W2017001937 hasOpenAccess W2017001937 @default.
- W2017001937 hasPrimaryLocation W20170019371 @default.
- W2017001937 hasRelatedWork W1877889068 @default.
- W2017001937 hasRelatedWork W1969050423 @default.
- W2017001937 hasRelatedWork W1982884673 @default.
- W2017001937 hasRelatedWork W2012616967 @default.
- W2017001937 hasRelatedWork W2026133741 @default.
- W2017001937 hasRelatedWork W2171225680 @default.