FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017001989> ?p ?o ?g. }

• W2017001989 endingPage "35" @default.
• W2017001989 startingPage "26" @default.
• W2017001989 abstract "C-fibers represent the majority of vagal afferents innervating the airways and lung, and can be activated by inhaled chemical irritants and certain endogenous substances. Stimulation of bronchopulmonary C-fibers with selective chemical activators by either inhalation or intravenous injection evokes irritation, burning and choking sensations in the throat, neck and upper chest (mid-sternum region) in healthy human subjects. These irritating sensations are often accompanied by bouts of coughs either during inhalation challenge or when a higher dose of the chemical activator is administered by intravenous injection. Dyspnea and breathless sensation are not always evoked when these afferents are activated by different types of chemical stimulants. This variability probably reflects the chemical nature of the stimulants, as well as the possibility that different subtypes of C-fibers encoded by different receptor proteins are activated. These respiratory sensations and reflex responses (e.g., cough) are believed to play an important role in protecting the lung against inhaled irritants and preventing overexertion under unusual physiological stresses (e.g., during strenuous exercise) in healthy individuals. More importantly, recent studies have revealed that the sensitivity of bronchopulmonary C-fibers can be markedly elevated in acute and chronic airway inflammatory diseases, probably caused by a sensitizing effect of certain endogenously released inflammatory mediators (e.g., prostaglandin E(2)) that act directly or indirectly on specific ion channels expressed on the sensory terminals. Normal physiological actions such as an increase in tidal volume (e.g., during mild exercise) can then activate these C-fiber afferents, and consequently may contribute, in part, to the lingering respiratory discomforts and other debilitating symptoms in patients with lung diseases." @default.
• W2017001989 created "2016-06-24" @default.
• W2017001989 creator A5039762450 @default.
• W2017001989 date "2009-05-01" @default.
• W2017001989 modified "2023-10-17" @default.
• W2017001989 title "Respiratory sensations evoked by activation of bronchopulmonary C-fibers" @default.
• W2017001989 cites W1485504360 @default.
• W2017001989 cites W1511198581 @default.
• W2017001989 cites W1544610129 @default.
• W2017001989 cites W1573321446 @default.
• W2017001989 cites W1793345278 @default.
• W2017001989 cites W1845234708 @default.
• W2017001989 cites W190138811 @default.
• W2017001989 cites W1963552543 @default.
• W2017001989 cites W1964328050 @default.
• W2017001989 cites W1970320316 @default.
• W2017001989 cites W1971579586 @default.
• W2017001989 cites W1973279084 @default.
• W2017001989 cites W1973488018 @default.
• W2017001989 cites W1981557279 @default.
• W2017001989 cites W1984617938 @default.
• W2017001989 cites W1986418361 @default.
• W2017001989 cites W1986880813 @default.
• W2017001989 cites W1988973105 @default.
• W2017001989 cites W1989311049 @default.
• W2017001989 cites W1995189884 @default.
• W2017001989 cites W1996199011 @default.
• W2017001989 cites W1999144988 @default.
• W2017001989 cites W2000285034 @default.
• W2017001989 cites W2003005465 @default.
• W2017001989 cites W2006560929 @default.
• W2017001989 cites W2008961677 @default.
• W2017001989 cites W2010049108 @default.
• W2017001989 cites W2012479782 @default.
• W2017001989 cites W2012909186 @default.
• W2017001989 cites W2018799018 @default.
• W2017001989 cites W2023028936 @default.
• W2017001989 cites W2030245254 @default.
• W2017001989 cites W2030675184 @default.
• W2017001989 cites W2031011141 @default.
• W2017001989 cites W2039640409 @default.
• W2017001989 cites W2039791136 @default.
• W2017001989 cites W2054837293 @default.
• W2017001989 cites W2057727396 @default.
• W2017001989 cites W2058921318 @default.
• W2017001989 cites W2061709150 @default.
• W2017001989 cites W2075584789 @default.
• W2017001989 cites W2076079527 @default.
• W2017001989 cites W2076268206 @default.
• W2017001989 cites W2079630582 @default.
• W2017001989 cites W2079682517 @default.
• W2017001989 cites W2087575545 @default.
• W2017001989 cites W2089193458 @default.
• W2017001989 cites W2090059155 @default.
• W2017001989 cites W2093970812 @default.
• W2017001989 cites W2105402135 @default.
• W2017001989 cites W2113719255 @default.
• W2017001989 cites W2114526670 @default.
• W2017001989 cites W2117468483 @default.
• W2017001989 cites W2124470549 @default.
• W2017001989 cites W2137292036 @default.
• W2017001989 cites W2140285237 @default.
• W2017001989 cites W2140363256 @default.
• W2017001989 cites W2144128379 @default.
• W2017001989 cites W2150336758 @default.
• W2017001989 cites W2150394630 @default.
• W2017001989 cites W2167511693 @default.
• W2017001989 cites W2168457138 @default.
• W2017001989 cites W2178372799 @default.
• W2017001989 cites W2313199871 @default.
• W2017001989 cites W2324356728 @default.
• W2017001989 cites W2337769108 @default.
• W2017001989 cites W2398278780 @default.
• W2017001989 cites W3022369430 @default.
• W2017001989 cites W56809197 @default.
• W2017001989 doi "https://doi.org/10.1016/j.resp.2008.05.006" @default.
• W2017001989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2759402" @default.
• W2017001989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18586581" @default.
• W2017001989 hasPublicationYear "2009" @default.
• W2017001989 type Work @default.
• W2017001989 sameAs 2017001989 @default.
• W2017001989 citedByCount "75" @default.
• W2017001989 countsByYear W20170019892012 @default.
• W2017001989 countsByYear W20170019892013 @default.
• W2017001989 countsByYear W20170019892014 @default.
• W2017001989 countsByYear W20170019892015 @default.
• W2017001989 countsByYear W20170019892016 @default.
• W2017001989 countsByYear W20170019892017 @default.
• W2017001989 countsByYear W20170019892018 @default.
• W2017001989 countsByYear W20170019892019 @default.
• W2017001989 countsByYear W20170019892020 @default.
• W2017001989 countsByYear W20170019892021 @default.
• W2017001989 countsByYear W20170019892022 @default.
• W2017001989 countsByYear W20170019892023 @default.
• W2017001989 crossrefType "journal-article" @default.
• W2017001989 hasAuthorship W2017001989A5039762450 @default.
• W2017001989 hasBestOaLocation W20170019892 @default.
• W2017001989 hasConcept C105922876 @default.

• next