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- W2017002430 abstract "Abstract Introduction and objective Despite recent findings reported on the nutritional factors that induce epigenetic changes, little information is available at early ages. This study analyzed in an experimental model, over two generations, potential changes in body composition and potential expression of epigenetic changes as the result of the intake of isoenergetic diets with different fat levels. Materials and methods At weaning, Wistar female rats were divided into two groups that were fed either a control diet (fat = 7%, w/w) or a high-fat diet (15%, w/w). Rats were mated at 70 days (M1) and their pups (P1) were the first generation; P1 rats were mated at 70 days (M2) and their pups (P2) represented the second generation. At weaning, mothers and pups (M1, M2 and P1, P2) were measured body weight (W) and composition (% body fat, %BF), and total skeleton bone mineral content (BMC), expressed as %BMC, using chemical and DXA methods, respectively. Results At weaning, high-fat diet groups M2 and P2 showed significant increases in W and %BF (p Conclusion This study demonstrates the need to review certain eating habits to avoid perpetuation of unhealthy patterns generation after generation." @default.
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- W2017002430 date "2012-04-01" @default.
- W2017002430 modified "2023-09-27" @default.
- W2017002430 title "High-fat diets and body composition over two generations. An experimental study" @default.
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- W2017002430 doi "https://doi.org/10.1016/j.endoen.2012.04.009" @default.
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