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- W2017003582 abstract "An ad-9 strain of Neurospora crassa was mutagenized with ethylmethane sulfonate (5%) and selected for guanine auxotrophy. The resultant double adenine plus guanine mutant was backcrossed with wild type and a single guanine auxotroph was isolated from the progeny. In vitro assays indicated that the mutant had GMP synthetase activity comparable with wild type, but was completely lacking in IMP dehydrogenase activity. The guanine requirement can therefore be explained by the mutant's inability to convert IMP to XMP. Another guanosine auxotroph was able to adapt and grow on minimal medium after 3 days. This mutant had GMP synthetase activity comparable with wild type but had only 10% of the IMP dehydrogenase activity of wild type, which may possibly explain its ability to grow on minimal medium after 3 days. It was confirmed that the two isolates are not allelic by crossing the two and recovering 25% wild-type progeny. Our isolate must therefore be designated gua-2." @default.
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- W2017003582 date "1980-12-01" @default.
- W2017003582 modified "2023-09-24" @default.
- W2017003582 title "Isolation and characterization of guanine auxotrophs in Neurospora crassa" @default.
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- W2017003582 doi "https://doi.org/10.1139/m80-235" @default.
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