FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017003813> ?p ?o ?g. }

• W2017003813 endingPage "969" @default.
• W2017003813 startingPage "959" @default.
• W2017003813 abstract "The adenosine diphosphate (ADP)-adenosine triphosphate (ATP) carrier of the inner mitochondrial membrane is identified as an autoantigen in myocarditis and dilated cardiomyopathy. Sera of patients with these diseases contain autoantibodies to the ADP-ATP carrier capable of inhibiting nucleotide transport in vitro. Recently, an antibody-related infringement of energy metabolism was shown in intact perfused hearts isolated from guinea pigs immunized with the ADP-ATP carrier. A decreased cytosolic-mitochondrial difference of the phosphorylation potential of ATP was measured that originated from a reduction in mitochondrial-cytosolic nucleotide transport. Nonimmunized animals did not show these changes in energy metabolism, despite being in a comparable metabolic state and performing equal external heart work. To establish whether antibodies to the ADP-ATP carrier can also alter cardiac function, hemodynamic parameters of isolated hearts of guinea pigs that were preimmunized with the carrier protein were measured. Cardiac metabolism was stimulated by exposing the hearts to a high calcium concentration in conjunction with a maximum elevation of the afterload. Mean aortic pressure, stroke volume, stroke work, and external heart work were found to be lowered significantly (p less than 0.005). The external heart work of the immunized hearts reached only about 20% of the level performed by control hearts. Myocardial oxygen consumption was lowered 2.5-fold, whereas the extent of lactate production was found to be more than doubled. These results show a diminished cardiac performance of hearts from animals immunized with the ADP-ATP carrier. Our findings demonstrate that autoimmunity to the ADP-ATP carrier may contribute to the pathophysiology of dilated cardiomyopathy as a subsequent stage of myocarditis by causing an autoantibody-mediated reduction in cardiac function on the basis of an imbalance between energy delivery and demand." @default.
• W2017003813 created "2016-06-24" @default.
• W2017003813 creator A5015927804 @default.
• W2017003813 creator A5036780717 @default.
• W2017003813 creator A5042610251 @default.
• W2017003813 creator A5044823395 @default.
• W2017003813 date "1990-03-01" @default.
• W2017003813 modified "2023-09-27" @default.
• W2017003813 title "Antibodies to ADP-ATP carrier--an autoantigen in myocarditis and dilated cardiomyopathy--impair cardiac function." @default.
• W2017003813 cites W1560019441 @default.
• W2017003813 cites W1588885776 @default.
• W2017003813 cites W1972326289 @default.
• W2017003813 cites W1978678285 @default.
• W2017003813 cites W1995343488 @default.
• W2017003813 cites W2010966624 @default.
• W2017003813 cites W2023144916 @default.
• W2017003813 cites W2027394148 @default.
• W2017003813 cites W2032552530 @default.
• W2017003813 cites W2038365440 @default.
• W2017003813 cites W2041634380 @default.
• W2017003813 cites W2045326559 @default.
• W2017003813 cites W2053359234 @default.
• W2017003813 cites W2063253626 @default.
• W2017003813 cites W2082626637 @default.
• W2017003813 cites W2085568008 @default.
• W2017003813 cites W21436401 @default.
• W2017003813 cites W2223492301 @default.
• W2017003813 cites W2319501942 @default.
• W2017003813 cites W937204623 @default.
• W2017003813 cites W1042608460 @default.
• W2017003813 doi "https://doi.org/10.1161/01.cir.81.3.959" @default.
• W2017003813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2155073" @default.
• W2017003813 hasPublicationYear "1990" @default.
• W2017003813 type Work @default.
• W2017003813 sameAs 2017003813 @default.
• W2017003813 citedByCount "174" @default.
• W2017003813 countsByYear W20170038132012 @default.
• W2017003813 countsByYear W20170038132013 @default.
• W2017003813 countsByYear W20170038132014 @default.
• W2017003813 countsByYear W20170038132015 @default.
• W2017003813 countsByYear W20170038132016 @default.
• W2017003813 countsByYear W20170038132017 @default.
• W2017003813 countsByYear W20170038132018 @default.
• W2017003813 countsByYear W20170038132019 @default.
• W2017003813 countsByYear W20170038132020 @default.
• W2017003813 countsByYear W20170038132022 @default.
• W2017003813 countsByYear W20170038132023 @default.
• W2017003813 crossrefType "journal-article" @default.
• W2017003813 hasAuthorship W2017003813A5015927804 @default.
• W2017003813 hasAuthorship W2017003813A5036780717 @default.
• W2017003813 hasAuthorship W2017003813A5042610251 @default.
• W2017003813 hasAuthorship W2017003813A5044823395 @default.
• W2017003813 hasBestOaLocation W20170038131 @default.
• W2017003813 hasConcept C104317684 @default.
• W2017003813 hasConcept C111566952 @default.
• W2017003813 hasConcept C126322002 @default.
• W2017003813 hasConcept C134018914 @default.
• W2017003813 hasConcept C20251656 @default.
• W2017003813 hasConcept C2776383484 @default.
• W2017003813 hasConcept C2777399203 @default.
• W2017003813 hasConcept C2778198053 @default.
• W2017003813 hasConcept C2778797674 @default.
• W2017003813 hasConcept C2779564974 @default.
• W2017003813 hasConcept C28859421 @default.
• W2017003813 hasConcept C2993802102 @default.
• W2017003813 hasConcept C2994266630 @default.
• W2017003813 hasConcept C512185932 @default.
• W2017003813 hasConcept C55493867 @default.
• W2017003813 hasConcept C62231903 @default.
• W2017003813 hasConcept C71924100 @default.
• W2017003813 hasConcept C86803240 @default.
• W2017003813 hasConcept C89560881 @default.
• W2017003813 hasConceptScore W2017003813C104317684 @default.
• W2017003813 hasConceptScore W2017003813C111566952 @default.
• W2017003813 hasConceptScore W2017003813C126322002 @default.
• W2017003813 hasConceptScore W2017003813C134018914 @default.
• W2017003813 hasConceptScore W2017003813C20251656 @default.
• W2017003813 hasConceptScore W2017003813C2776383484 @default.
• W2017003813 hasConceptScore W2017003813C2777399203 @default.
• W2017003813 hasConceptScore W2017003813C2778198053 @default.
• W2017003813 hasConceptScore W2017003813C2778797674 @default.
• W2017003813 hasConceptScore W2017003813C2779564974 @default.
• W2017003813 hasConceptScore W2017003813C28859421 @default.
• W2017003813 hasConceptScore W2017003813C2993802102 @default.
• W2017003813 hasConceptScore W2017003813C2994266630 @default.
• W2017003813 hasConceptScore W2017003813C512185932 @default.
• W2017003813 hasConceptScore W2017003813C55493867 @default.
• W2017003813 hasConceptScore W2017003813C62231903 @default.
• W2017003813 hasConceptScore W2017003813C71924100 @default.
• W2017003813 hasConceptScore W2017003813C86803240 @default.
• W2017003813 hasConceptScore W2017003813C89560881 @default.
• W2017003813 hasIssue "3" @default.
• W2017003813 hasLocation W20170038131 @default.
• W2017003813 hasLocation W20170038132 @default.
• W2017003813 hasOpenAccess W2017003813 @default.
• W2017003813 hasPrimaryLocation W20170038131 @default.
• W2017003813 hasRelatedWork W1993358840 @default.
• W2017003813 hasRelatedWork W2016505924 @default.

• next