Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017005428> ?p ?o ?g. }
- W2017005428 endingPage "267" @default.
- W2017005428 startingPage "251" @default.
- W2017005428 abstract "Lampbrush chromosomes (LBCs) are highly extended bivalents that function in the growing oocytes of many animals. Due to their distinctive chromomere-loop organization and intense transcriptional activity of lateral loops the LBCs, mainly amphibian ones, have served as a powerful system for exploring the general principles of chromosome organization and function. The exploitation of avian LBCs has considerably broadened the opportunities for comparative genome research and for cytogenetic analysis of domestic species. In this review we highlight the advantages of avian LBCs for research in different areas including integration of genome organization studies with studies on gene activity in vivo, analysis of co-transcriptional events occurring on nascent transcripts and investigation of chromosome-associated intranuclear domains. Recent findings concerning the organization of transcriptionally active and silent chromatin together with involvement of cohesin and condensin complexes into maintenance of structural integrity of LBCs are presented. The biological significance of the LBC phenomenon is discussed. The intensive transcription on LBCs shows some specific features: very long transcription units, deregulated termination, and transcription of non-coding satellite repeats. Here, based on the modern view on a role of RNA interference machinery in regulation of genome expression, we suggest a mechanism of initiation of satellite DNA transcription and offer a novel interpretation of the 'classical' hypothesis that sought to explain the significance of widespread transcription during oocyte growth." @default.
- W2017005428 created "2016-06-24" @default.
- W2017005428 creator A5055325745 @default.
- W2017005428 creator A5071558914 @default.
- W2017005428 creator A5091665303 @default.
- W2017005428 date "2009-01-01" @default.
- W2017005428 modified "2023-10-17" @default.
- W2017005428 title "Avian Lampbrush Chromosomes: a Powerful Tool for Exploration of Genome Expression" @default.
- W2017005428 cites W1485943120 @default.
- W2017005428 cites W1495632409 @default.
- W2017005428 cites W1554654621 @default.
- W2017005428 cites W1597584782 @default.
- W2017005428 cites W170268241 @default.
- W2017005428 cites W1943544165 @default.
- W2017005428 cites W1965045326 @default.
- W2017005428 cites W1966252793 @default.
- W2017005428 cites W1970036299 @default.
- W2017005428 cites W1970233755 @default.
- W2017005428 cites W1970535309 @default.
- W2017005428 cites W1971733888 @default.
- W2017005428 cites W1973937629 @default.
- W2017005428 cites W1991676057 @default.
- W2017005428 cites W1994445230 @default.
- W2017005428 cites W2002699652 @default.
- W2017005428 cites W2006454485 @default.
- W2017005428 cites W2008553523 @default.
- W2017005428 cites W2008605645 @default.
- W2017005428 cites W2013907950 @default.
- W2017005428 cites W2014576781 @default.
- W2017005428 cites W2016066165 @default.
- W2017005428 cites W2019988824 @default.
- W2017005428 cites W2021149998 @default.
- W2017005428 cites W2027937559 @default.
- W2017005428 cites W2028001301 @default.
- W2017005428 cites W2028274544 @default.
- W2017005428 cites W2032972166 @default.
- W2017005428 cites W2035390069 @default.
- W2017005428 cites W2035756674 @default.
- W2017005428 cites W2038953290 @default.
- W2017005428 cites W2042292065 @default.
- W2017005428 cites W2045194790 @default.
- W2017005428 cites W2046168172 @default.
- W2017005428 cites W2047661264 @default.
- W2017005428 cites W2053692995 @default.
- W2017005428 cites W2055335294 @default.
- W2017005428 cites W2060637445 @default.
- W2017005428 cites W2060786128 @default.
- W2017005428 cites W2063106289 @default.
- W2017005428 cites W2063360888 @default.
- W2017005428 cites W2065296418 @default.
- W2017005428 cites W2066511342 @default.
- W2017005428 cites W2069041747 @default.
- W2017005428 cites W2070831458 @default.
- W2017005428 cites W2078059481 @default.
- W2017005428 cites W2081249189 @default.
- W2017005428 cites W2089492417 @default.
- W2017005428 cites W2089852262 @default.
- W2017005428 cites W209218854 @default.
- W2017005428 cites W2098805590 @default.
- W2017005428 cites W2101679570 @default.
- W2017005428 cites W2105412398 @default.
- W2017005428 cites W2108580005 @default.
- W2017005428 cites W2110753555 @default.
- W2017005428 cites W2111833499 @default.
- W2017005428 cites W2112528175 @default.
- W2017005428 cites W2112551742 @default.
- W2017005428 cites W2113914143 @default.
- W2017005428 cites W2114979281 @default.
- W2017005428 cites W2118506786 @default.
- W2017005428 cites W2120290297 @default.
- W2017005428 cites W2121435940 @default.
- W2017005428 cites W2122289183 @default.
- W2017005428 cites W2133884785 @default.
- W2017005428 cites W2138202564 @default.
- W2017005428 cites W2139316493 @default.
- W2017005428 cites W2141470618 @default.
- W2017005428 cites W2144241077 @default.
- W2017005428 cites W2152004018 @default.
- W2017005428 cites W2159666069 @default.
- W2017005428 cites W2164446171 @default.
- W2017005428 cites W2164588795 @default.
- W2017005428 cites W2168849752 @default.
- W2017005428 cites W2169135550 @default.
- W2017005428 cites W2171047101 @default.
- W2017005428 cites W2182827955 @default.
- W2017005428 cites W2183098907 @default.
- W2017005428 cites W2185049500 @default.
- W2017005428 cites W2255874941 @default.
- W2017005428 cites W2292621739 @default.
- W2017005428 cites W2395656141 @default.
- W2017005428 cites W2410918020 @default.
- W2017005428 cites W2411528700 @default.
- W2017005428 cites W2411573499 @default.
- W2017005428 cites W2415956277 @default.
- W2017005428 cites W2429182291 @default.
- W2017005428 cites W2434944611 @default.
- W2017005428 cites W2465236726 @default.
- W2017005428 cites W2466391751 @default.