Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017005906> ?p ?o ?g. }
- W2017005906 endingPage "217" @default.
- W2017005906 startingPage "208" @default.
- W2017005906 abstract "The effects of infusing human alpha-calcitonin gene-related peptide were studied in eight patients with congestive heart failure, five normal rabbits and five rabbits with adriamycin-induced cardiomyopathy. In patients with heart failure, calcitonin gene-related peptide caused a dose-dependent increase in cardiac output and decrease in pulmonary and systemic vascular resistance and pulmonary artery pressure. The systemic blood pressure and right atrial and pulmonary wedge pressures decreased only at the highest infusion rate (16 ng/kg per min). Heart rate remained unchanged. Plasma epinephrine increased (p less than 0.05), whereas aldosterone, atrial natriuretic peptide and prolactin concentrations decreased (p less than 0.05). Plasma norepinephrine, renin activity, cortisol and growth hormone concentrations remained unchanged. In both groups of rabbits, the drug decreased blood pressure and increased cardiac output and heart rate. There was a significant increase in renal blood flow (p less than 0.05). The peptide did not affect the contraction amplitude of human and rabbit ventricular myocytes. These findings suggest that calcitonin gene-related peptide is a vasodilator in the rabbit and humans with little direct effect on ventricular myocardium. This peptide may be useful in some forms of heart failure." @default.
- W2017005906 created "2016-06-24" @default.
- W2017005906 creator A5007353842 @default.
- W2017005906 creator A5014693392 @default.
- W2017005906 creator A5023104782 @default.
- W2017005906 creator A5035352404 @default.
- W2017005906 creator A5055266997 @default.
- W2017005906 creator A5056300955 @default.
- W2017005906 creator A5062655570 @default.
- W2017005906 creator A5064124303 @default.
- W2017005906 creator A5069427417 @default.
- W2017005906 creator A5081598593 @default.
- W2017005906 date "1991-01-01" @default.
- W2017005906 modified "2023-09-27" @default.
- W2017005906 title "Cardiovascular and hormonal effects of calcitonin gene-related peptide in congestive heart failure" @default.
- W2017005906 cites W1591270417 @default.
- W2017005906 cites W1604277549 @default.
- W2017005906 cites W173746587 @default.
- W2017005906 cites W1980309034 @default.
- W2017005906 cites W1988183722 @default.
- W2017005906 cites W1993576134 @default.
- W2017005906 cites W1994060276 @default.
- W2017005906 cites W1996842876 @default.
- W2017005906 cites W1997201378 @default.
- W2017005906 cites W2007439206 @default.
- W2017005906 cites W2010916378 @default.
- W2017005906 cites W2012362039 @default.
- W2017005906 cites W2016299086 @default.
- W2017005906 cites W2029253166 @default.
- W2017005906 cites W2030411045 @default.
- W2017005906 cites W2035581625 @default.
- W2017005906 cites W2041403941 @default.
- W2017005906 cites W2042173818 @default.
- W2017005906 cites W2050553285 @default.
- W2017005906 cites W2052385273 @default.
- W2017005906 cites W2057315384 @default.
- W2017005906 cites W2057539756 @default.
- W2017005906 cites W2058639371 @default.
- W2017005906 cites W2063247952 @default.
- W2017005906 cites W2066978645 @default.
- W2017005906 cites W2070049849 @default.
- W2017005906 cites W2083402694 @default.
- W2017005906 cites W2087427200 @default.
- W2017005906 cites W2094764717 @default.
- W2017005906 cites W2102686195 @default.
- W2017005906 cites W2154922265 @default.
- W2017005906 cites W2270145003 @default.
- W2017005906 cites W2323331707 @default.
- W2017005906 cites W2470047386 @default.
- W2017005906 cites W654795110 @default.
- W2017005906 doi "https://doi.org/10.1016/0735-1097(91)90729-s" @default.
- W2017005906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1987228" @default.
- W2017005906 hasPublicationYear "1991" @default.
- W2017005906 type Work @default.
- W2017005906 sameAs 2017005906 @default.
- W2017005906 citedByCount "31" @default.
- W2017005906 countsByYear W20170059062014 @default.
- W2017005906 countsByYear W20170059062015 @default.
- W2017005906 countsByYear W20170059062018 @default.
- W2017005906 countsByYear W20170059062019 @default.
- W2017005906 crossrefType "journal-article" @default.
- W2017005906 hasAuthorship W2017005906A5007353842 @default.
- W2017005906 hasAuthorship W2017005906A5014693392 @default.
- W2017005906 hasAuthorship W2017005906A5023104782 @default.
- W2017005906 hasAuthorship W2017005906A5035352404 @default.
- W2017005906 hasAuthorship W2017005906A5055266997 @default.
- W2017005906 hasAuthorship W2017005906A5056300955 @default.
- W2017005906 hasAuthorship W2017005906A5062655570 @default.
- W2017005906 hasAuthorship W2017005906A5064124303 @default.
- W2017005906 hasAuthorship W2017005906A5069427417 @default.
- W2017005906 hasAuthorship W2017005906A5081598593 @default.
- W2017005906 hasBestOaLocation W20170059061 @default.
- W2017005906 hasConcept C118303440 @default.
- W2017005906 hasConcept C120770815 @default.
- W2017005906 hasConcept C126322002 @default.
- W2017005906 hasConcept C134018914 @default.
- W2017005906 hasConcept C138976137 @default.
- W2017005906 hasConcept C139940330 @default.
- W2017005906 hasConcept C163170386 @default.
- W2017005906 hasConcept C170493617 @default.
- W2017005906 hasConcept C198710026 @default.
- W2017005906 hasConcept C2777953023 @default.
- W2017005906 hasConcept C2778069365 @default.
- W2017005906 hasConcept C2778198053 @default.
- W2017005906 hasConcept C2778525890 @default.
- W2017005906 hasConcept C2780940725 @default.
- W2017005906 hasConcept C58245268 @default.
- W2017005906 hasConcept C71924100 @default.
- W2017005906 hasConcept C84393581 @default.
- W2017005906 hasConceptScore W2017005906C118303440 @default.
- W2017005906 hasConceptScore W2017005906C120770815 @default.
- W2017005906 hasConceptScore W2017005906C126322002 @default.
- W2017005906 hasConceptScore W2017005906C134018914 @default.
- W2017005906 hasConceptScore W2017005906C138976137 @default.
- W2017005906 hasConceptScore W2017005906C139940330 @default.
- W2017005906 hasConceptScore W2017005906C163170386 @default.
- W2017005906 hasConceptScore W2017005906C170493617 @default.
- W2017005906 hasConceptScore W2017005906C198710026 @default.