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- W2017007957 abstract "The rapid and direct delivery of a neuroactive endomorphin 1 derivative to the brain via nasal delivery is reported. A synthetic derivative of the native opioid peptide, endomorphin 1 bearing a lactose unit on the N-terminus of the peptide has been previously reported to exhibit antinoceceptive activity similar to morphine after both intravenous and oral administration. This compound has been administered nasally to rats and appeared in the olfactory bulb within 10 min of administration with negligible levels appearing in the circulating blood or in the rest of the brain. These results indicate that the peptide is absorbed into the brain via the olfactory epithelial pathway suggesting nasal delivery may be a viable alternative route of delivery in clinical applications." @default.
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- W2017007957 date "2014-03-01" @default.
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- W2017007957 title "Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway" @default.
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- W2017007957 doi "https://doi.org/10.1016/j.bmcl.2014.01.041" @default.
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