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- W2017008316 abstract "Of three nucleases induced by poxvirus, one is a nuclease that acts on denatured DNA at acid pH values. This enzyme has been purified over 3000-fold and has the following characteristics: It degrades heat-denatured DNA exonucleolytically but has negligible activity toward native DNA or RNA; the degradation of denatured DNA is not inhibited by native DNA but is competitively inhibited by sRNA; there is no requirement for added divalent cations; the pH optimum for the degradation of denatured DNA is 4.5, a pH at which the enzyme is insoluble; the enzyme has a Km of 7.7 × 10−6 g and an S20ow of 5.8 ± 0.3. There is no detectable enzyme activity with all of these characteristics in uninfected cells. In contrast to the other poxvirus-induced nucleases, the acid nuclease is synthesized under the direction of only progeny DNA templates. During the course of viral infection the enzyme undergoes a sharp transition, in vivo, from a soluble to bound state but is synthesized continuously for about 18 hours postinfection." @default.
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- W2017008316 date "1967-12-01" @default.
- W2017008316 modified "2023-09-23" @default.
- W2017008316 title "Poxvirus-induced acid deoxyribonuclease: Regulation of synthesis; Control of activity in vivo; Purification and properties of the enzyme" @default.
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- W2017008316 doi "https://doi.org/10.1016/0042-6822(67)90071-2" @default.
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