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- W2017008536 abstract "ABSTRACT The problem of identifying the minimum effective dose (MED) in a dose-response study is considered, where the MED is defined to be the lowest dose level with a mean response greater than that of the zero-dose control. This article adapts a step-down procedure with modified step contrasts to determine the MED. An approximation for obtaining the critical values and p-values of the proposed procedure is described. The proposed procedure is compared with some other contrasts procedures in a simulation study. It is pointed out that, when the true MED is the first dose level, in which no FWEs are involved, the proposed procedure has great power and is recommended for the use of identifying the MED." @default.
- W2017008536 created "2016-06-24" @default.
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- W2017008536 date "2005-02-09" @default.
- W2017008536 modified "2023-09-27" @default.
- W2017008536 title "Step Contrasts for Identifying the Minimum Effective Dose" @default.
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- W2017008536 doi "https://doi.org/10.1081/sta-200045872" @default.
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