FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017008893> ?p ?o ?g. }

• W2017008893 endingPage "279" @default.
• W2017008893 startingPage "262" @default.
• W2017008893 abstract "We designed a cell culture-based system to test the hypothesis that recombination events during HIV-1 replication would be more frequent near the dimerization initiation sequence (DIS). A 459-bp region spanning the DIS through the 5′-end of gag was sequenced and analyzed to determine the frequency and distribution of crossover sites. We found a strong preference for recombination events occurring within a 112-nt-long region encompassing the gag AUG (64% of crossovers occurred in this region, compared to 10–14% in surrounding regions with similar lengths). Surprisingly, the region immediately surrounding the DIS was not a preferred site of recombination. Analysis of recombination events using RNA templates transcribed in vitro revealed a preference for crossover sites at the start of the gag coding region, similar to that observed in cell culture. This recombinogenic region was unusually G-rich and promoted extensive pausing by RT in vitro. Template features that induce RT pausing very likely contribute to the observed template switching events in gag during minus-strand synthesis. The region in gag that was a preferred site for recombination also had an approximately 2-fold higher mutation frequency compared to the rest of the region sequenced, but mutations were no more common in recombinant compared to non-recombinant clones, suggesting that recombination events were not mutagenic." @default.
• W2017008893 created "2016-06-24" @default.
• W2017008893 creator A5002269399 @default.
• W2017008893 creator A5005315226 @default.
• W2017008893 creator A5012789809 @default.
• W2017008893 creator A5025036146 @default.
• W2017008893 creator A5042773644 @default.
• W2017008893 creator A5057349004 @default.
• W2017008893 date "2004-09-01" @default.
• W2017008893 modified "2023-10-16" @default.
• W2017008893 title "Identification of a preferred region for recombination and mutation in HIV-1 gag" @default.
• W2017008893 cites W1480555318 @default.
• W2017008893 cites W1575305367 @default.
• W2017008893 cites W1579646504 @default.
• W2017008893 cites W1581921347 @default.
• W2017008893 cites W1591189766 @default.
• W2017008893 cites W1673293585 @default.
• W2017008893 cites W1711343352 @default.
• W2017008893 cites W1763313231 @default.
• W2017008893 cites W1967396825 @default.
• W2017008893 cites W1968937894 @default.
• W2017008893 cites W1985376112 @default.
• W2017008893 cites W2011099775 @default.
• W2017008893 cites W2023035407 @default.
• W2017008893 cites W2027051533 @default.
• W2017008893 cites W2028654103 @default.
• W2017008893 cites W2034703213 @default.
• W2017008893 cites W2037450520 @default.
• W2017008893 cites W2039724561 @default.
• W2017008893 cites W2056134410 @default.
• W2017008893 cites W2064166253 @default.
• W2017008893 cites W2064475194 @default.
• W2017008893 cites W2065740427 @default.
• W2017008893 cites W2070911609 @default.
• W2017008893 cites W2072819545 @default.
• W2017008893 cites W2073004681 @default.
• W2017008893 cites W2073295047 @default.
• W2017008893 cites W2077246276 @default.
• W2017008893 cites W2080589169 @default.
• W2017008893 cites W2087946368 @default.
• W2017008893 cites W2090126383 @default.
• W2017008893 cites W2090131332 @default.
• W2017008893 cites W2097001494 @default.
• W2017008893 cites W2098524212 @default.
• W2017008893 cites W2117623876 @default.
• W2017008893 cites W2119122259 @default.
• W2017008893 cites W2120724470 @default.
• W2017008893 cites W2122406382 @default.
• W2017008893 cites W2123805590 @default.
• W2017008893 cites W2124420621 @default.
• W2017008893 cites W2130582243 @default.
• W2017008893 cites W2132674999 @default.
• W2017008893 cites W2139429914 @default.
• W2017008893 cites W2139653511 @default.
• W2017008893 cites W2147588454 @default.
• W2017008893 cites W2151164700 @default.
• W2017008893 cites W2151292912 @default.
• W2017008893 cites W2152114427 @default.
• W2017008893 cites W2152832611 @default.
• W2017008893 cites W2154632774 @default.
• W2017008893 cites W2154871837 @default.
• W2017008893 cites W2166632146 @default.
• W2017008893 cites W2168356543 @default.
• W2017008893 cites W2171013248 @default.
• W2017008893 doi "https://doi.org/10.1016/j.virol.2004.02.033" @default.
• W2017008893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15302212" @default.
• W2017008893 hasPublicationYear "2004" @default.
• W2017008893 type Work @default.
• W2017008893 sameAs 2017008893 @default.
• W2017008893 citedByCount "41" @default.
• W2017008893 countsByYear W20170088932012 @default.
• W2017008893 countsByYear W20170088932013 @default.
• W2017008893 countsByYear W20170088932014 @default.
• W2017008893 countsByYear W20170088932015 @default.
• W2017008893 countsByYear W20170088932016 @default.
• W2017008893 countsByYear W20170088932018 @default.
• W2017008893 countsByYear W20170088932019 @default.
• W2017008893 countsByYear W20170088932021 @default.
• W2017008893 countsByYear W20170088932023 @default.
• W2017008893 crossrefType "journal-article" @default.
• W2017008893 hasAuthorship W2017008893A5002269399 @default.
• W2017008893 hasAuthorship W2017008893A5005315226 @default.
• W2017008893 hasAuthorship W2017008893A5012789809 @default.
• W2017008893 hasAuthorship W2017008893A5025036146 @default.
• W2017008893 hasAuthorship W2017008893A5042773644 @default.
• W2017008893 hasAuthorship W2017008893A5057349004 @default.
• W2017008893 hasConcept C102306862 @default.
• W2017008893 hasConcept C104317684 @default.
• W2017008893 hasConcept C153911025 @default.
• W2017008893 hasConcept C156695909 @default.
• W2017008893 hasConcept C40767141 @default.
• W2017008893 hasConcept C501734568 @default.
• W2017008893 hasConcept C54355233 @default.
• W2017008893 hasConcept C552990157 @default.
• W2017008893 hasConcept C67705224 @default.
• W2017008893 hasConcept C86803240 @default.
• W2017008893 hasConcept C91779695 @default.
• W2017008893 hasConceptScore W2017008893C102306862 @default.

• next