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- W2017009056 abstract "The correlation between urolithiasis due to uracil administration and epithelial proliferation in the urinary bladder was investigated in male F344 rats. Animals, 6 weeks old at the start, which ingested 3% uracil alone in the diet for 4 weeks developed urolithiasis and papillomatosis of the urinary bladder, whereas addition of NaCl, particularly at high concentration (10%), to the 3% uracil in the diet blocked production of both. In contrast, NaHCO3 was without influence on either calculi or proliferative changes. These results indicate that uracil-induced epithelial proliferation is due to direct mechanical irritation by calculi, and not to any chemical stimulus presented by uracil itself." @default.
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- W2017009056 date "1992-06-01" @default.
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- W2017009056 title "Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent" @default.
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- W2017009056 doi "https://doi.org/10.1016/0378-4274(92)90059-s" @default.
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