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- W2017009542 abstract "Warfarin is a frequently used oral anticoagulant for long-term prevention and treatment of thromboembolic events. Due to its narrow therapeutic range and large inter-individual dose–response variability, it is highly desirable to personalize warfarin dosing. However, the complexity of the conventional kinetic-pharmacodynamic (K-PD) models hampers the development of the personalized dose management. To avert this challenge, we propose simplified PD models for warfarin dose-INR response relationship, which is motivated by ideas from control theory. The simplified models were further applied to longitudinal data of 37 patients undergoing anticoagulation treatment using the standard two-stage approach and then compared with the conventional K-PD models. Data analysis shows that all models have a similar predictive ability, but the simplified models are most parsimonious." @default.
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- W2017009542 date "2015-02-01" @default.
- W2017009542 modified "2023-09-25" @default.
- W2017009542 title "SIMPLIFIED WARFARIN DOSE–RESPONSE PHARMACODYNAMIC MODELS" @default.
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- W2017009542 doi "https://doi.org/10.4015/s1016237215500015" @default.
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