Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017009575> ?p ?o ?g. }
- W2017009575 endingPage "847" @default.
- W2017009575 startingPage "821" @default.
- W2017009575 abstract "Drosophila visual transduction is the fastest known G-protein-coupled signaling cascade and has therefore served as a genetically tractable animal model for characterizing rapid responses to sensory stimulation. Mutations in over 30 genes have been identified, which affect activation, adaptation, or termination of the photoresponse. Based on analyses of these genes, a model for phototransduction has emerged, which involves phosphoinoside signaling and culminates with opening of the TRP and TRPL cation channels. Many of the proteins that function in phototransduction are coupled to the PDZ containing scaffold protein INAD and form a supramolecular signaling complex, the signalplex. Arrestin, TRPL, and Gαq undergo dynamic light-dependent trafficking, and these movements function in long-term adaptation. Other proteins play important roles either in the formation or maturation of rhodopsin, or in regeneration of phosphatidylinositol 4,5-bisphosphate (PIP2), which is required for the photoresponse. Mutation of nearly any gene that functions in the photoresponse results in retinal degeneration. The underlying bases of photoreceptor cell death are diverse and involve mechanisms such as excessive endocytosis of rhodopsin due to stable rhodopsin/arrestin complexes and abnormally low or high levels of Ca2+. Drosophila visual transduction appears to have particular relevance to the cascade in the intrinsically photosensitive retinal ganglion cells in mammals, as the photoresponse in these latter cells appears to operate through a remarkably similar mechanism." @default.
- W2017009575 created "2016-06-24" @default.
- W2017009575 creator A5023339844 @default.
- W2017009575 creator A5059045594 @default.
- W2017009575 date "2007-05-09" @default.
- W2017009575 modified "2023-10-02" @default.
- W2017009575 title "Phototransduction and retinal degeneration in Drosophila" @default.
- W2017009575 cites W121680641 @default.
- W2017009575 cites W1483542781 @default.
- W2017009575 cites W1483885724 @default.
- W2017009575 cites W1490866393 @default.
- W2017009575 cites W1498936781 @default.
- W2017009575 cites W1508377277 @default.
- W2017009575 cites W1509760806 @default.
- W2017009575 cites W1511847553 @default.
- W2017009575 cites W1527359679 @default.
- W2017009575 cites W1530376792 @default.
- W2017009575 cites W1537970310 @default.
- W2017009575 cites W1544613378 @default.
- W2017009575 cites W1562615854 @default.
- W2017009575 cites W1575291279 @default.
- W2017009575 cites W1595948784 @default.
- W2017009575 cites W1607531254 @default.
- W2017009575 cites W1614420319 @default.
- W2017009575 cites W1620578262 @default.
- W2017009575 cites W1658150383 @default.
- W2017009575 cites W1791826861 @default.
- W2017009575 cites W1817796286 @default.
- W2017009575 cites W1829183716 @default.
- W2017009575 cites W1836418894 @default.
- W2017009575 cites W187222491 @default.
- W2017009575 cites W1879257160 @default.
- W2017009575 cites W1919843837 @default.
- W2017009575 cites W1932075839 @default.
- W2017009575 cites W1949683075 @default.
- W2017009575 cites W1964200801 @default.
- W2017009575 cites W1965863612 @default.
- W2017009575 cites W1970042814 @default.
- W2017009575 cites W1970286448 @default.
- W2017009575 cites W1971524741 @default.
- W2017009575 cites W1974135959 @default.
- W2017009575 cites W1974768178 @default.
- W2017009575 cites W1975056846 @default.
- W2017009575 cites W1975714781 @default.
- W2017009575 cites W1977374078 @default.
- W2017009575 cites W1981049634 @default.
- W2017009575 cites W1981057134 @default.
- W2017009575 cites W1983127589 @default.
- W2017009575 cites W1984116068 @default.
- W2017009575 cites W1984540130 @default.
- W2017009575 cites W1984764741 @default.
- W2017009575 cites W1986599659 @default.
- W2017009575 cites W1987500506 @default.
- W2017009575 cites W1988190084 @default.
- W2017009575 cites W1989040340 @default.
- W2017009575 cites W1989141400 @default.
- W2017009575 cites W1989868645 @default.
- W2017009575 cites W1990140467 @default.
- W2017009575 cites W1990504906 @default.
- W2017009575 cites W1991148544 @default.
- W2017009575 cites W1991536318 @default.
- W2017009575 cites W1993053934 @default.
- W2017009575 cites W1995155011 @default.
- W2017009575 cites W1995481744 @default.
- W2017009575 cites W1995692886 @default.
- W2017009575 cites W1996509463 @default.
- W2017009575 cites W1996764186 @default.
- W2017009575 cites W1997853762 @default.
- W2017009575 cites W2001842588 @default.
- W2017009575 cites W2002260905 @default.
- W2017009575 cites W2003571870 @default.
- W2017009575 cites W2003598465 @default.
- W2017009575 cites W2003943085 @default.
- W2017009575 cites W2005557667 @default.
- W2017009575 cites W2006842412 @default.
- W2017009575 cites W2007146740 @default.
- W2017009575 cites W2007354719 @default.
- W2017009575 cites W2007416260 @default.
- W2017009575 cites W2010689036 @default.
- W2017009575 cites W2012398649 @default.
- W2017009575 cites W2014325599 @default.
- W2017009575 cites W2014893784 @default.
- W2017009575 cites W2015426350 @default.
- W2017009575 cites W2015826089 @default.
- W2017009575 cites W2016170285 @default.
- W2017009575 cites W2016969524 @default.
- W2017009575 cites W2017744980 @default.
- W2017009575 cites W2018575922 @default.
- W2017009575 cites W2019920766 @default.
- W2017009575 cites W2020699084 @default.
- W2017009575 cites W2022268067 @default.
- W2017009575 cites W2022735531 @default.
- W2017009575 cites W2022788495 @default.
- W2017009575 cites W2022864334 @default.
- W2017009575 cites W2023025537 @default.
- W2017009575 cites W2023296324 @default.
- W2017009575 cites W2025954712 @default.
- W2017009575 cites W2026042821 @default.