Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017011135> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2017011135 endingPage "883" @default.
- W2017011135 startingPage "873" @default.
- W2017011135 abstract "This study presents the expression pattern and functions of thymosin beta 10 (Tbeta10), a Tbeta4 homologue during the development of mouse lower first molars. An in situ signal of Tbeta10 was detected on embryonic day 10.5 (E10.5)-E15.5 mainly in dental mesenchymal cells as well as in dental epithelial cells, while Tbeta4 was expressed in dental epithelial cells. In the late bell stage, preodontoblasts with strong Tbeta10 expression and preameloblasts with strong Tbeta4 expression exhibited face-to-face localization, suggesting that an intimate cell-cell interaction might exist between preodontoblasts and preameloblasts to form dentin and enamel matrices. A strong Tbeta10 signal was found in odontoblasts in the lateral side of the dental pulp and in Hertwig’s epithelial root sheath, thus suggesting that Tbeta10 participates in the formation of the outline of the tooth root. An inhibition assay using Tbeta10-siRNA in E11.0 mandibles showed significant growth inhibition in the tooth germ. The Tbeta10-siRNA-treated E15.0 tooth germ also showed significant developmental arrest. The number of Ki67-positive cells significantly decreased in the Tbeta10-siRNA-treated mandibles. The cellular proliferative activity was also significantly suppressed in Tb10-siRNA-treated cultured mouse dental pulpal and epithelial cells. These results indicate that developmental arrest of the tooth germ might be caused by a reduction in cell proliferative activity. The stage-specific temporal and spatial expression pattern of Tbeta10 in the developing tooth germ is indicative of multiple functions of Tbeta10 in the developmental course from initiation to root formation of the tooth germ." @default.
- W2017011135 created "2016-06-24" @default.
- W2017011135 creator A5026897299 @default.
- W2017011135 creator A5038581708 @default.
- W2017011135 creator A5052851363 @default.
- W2017011135 creator A5060137813 @default.
- W2017011135 creator A5065822023 @default.
- W2017011135 creator A5067269475 @default.
- W2017011135 creator A5074997783 @default.
- W2017011135 creator A5082098145 @default.
- W2017011135 creator A5082506477 @default.
- W2017011135 creator A5085389672 @default.
- W2017011135 date "2013-01-01" @default.
- W2017011135 modified "2023-10-14" @default.
- W2017011135 title "The expression and function of thymosin beta 10 in tooth germ development" @default.
- W2017011135 doi "https://doi.org/10.1387/ijdb.120240hs" @default.
- W2017011135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24623079" @default.
- W2017011135 hasPublicationYear "2013" @default.
- W2017011135 type Work @default.
- W2017011135 sameAs 2017011135 @default.
- W2017011135 citedByCount "11" @default.
- W2017011135 countsByYear W20170111352014 @default.
- W2017011135 countsByYear W20170111352015 @default.
- W2017011135 countsByYear W20170111352016 @default.
- W2017011135 countsByYear W20170111352017 @default.
- W2017011135 countsByYear W20170111352018 @default.
- W2017011135 countsByYear W20170111352021 @default.
- W2017011135 countsByYear W20170111352022 @default.
- W2017011135 crossrefType "journal-article" @default.
- W2017011135 hasAuthorship W2017011135A5026897299 @default.
- W2017011135 hasAuthorship W2017011135A5038581708 @default.
- W2017011135 hasAuthorship W2017011135A5052851363 @default.
- W2017011135 hasAuthorship W2017011135A5060137813 @default.
- W2017011135 hasAuthorship W2017011135A5065822023 @default.
- W2017011135 hasAuthorship W2017011135A5067269475 @default.
- W2017011135 hasAuthorship W2017011135A5074997783 @default.
- W2017011135 hasAuthorship W2017011135A5082098145 @default.
- W2017011135 hasAuthorship W2017011135A5082506477 @default.
- W2017011135 hasAuthorship W2017011135A5085389672 @default.
- W2017011135 hasBestOaLocation W20170111351 @default.
- W2017011135 hasConcept C104317684 @default.
- W2017011135 hasConcept C105702510 @default.
- W2017011135 hasConcept C142724271 @default.
- W2017011135 hasConcept C145103041 @default.
- W2017011135 hasConcept C151730666 @default.
- W2017011135 hasConcept C16685009 @default.
- W2017011135 hasConcept C188442228 @default.
- W2017011135 hasConcept C202271784 @default.
- W2017011135 hasConcept C203014093 @default.
- W2017011135 hasConcept C2520015 @default.
- W2017011135 hasConcept C2776451592 @default.
- W2017011135 hasConcept C2779122487 @default.
- W2017011135 hasConcept C2779263046 @default.
- W2017011135 hasConcept C54355233 @default.
- W2017011135 hasConcept C62112901 @default.
- W2017011135 hasConcept C71924100 @default.
- W2017011135 hasConcept C86803240 @default.
- W2017011135 hasConcept C95444343 @default.
- W2017011135 hasConceptScore W2017011135C104317684 @default.
- W2017011135 hasConceptScore W2017011135C105702510 @default.
- W2017011135 hasConceptScore W2017011135C142724271 @default.
- W2017011135 hasConceptScore W2017011135C145103041 @default.
- W2017011135 hasConceptScore W2017011135C151730666 @default.
- W2017011135 hasConceptScore W2017011135C16685009 @default.
- W2017011135 hasConceptScore W2017011135C188442228 @default.
- W2017011135 hasConceptScore W2017011135C202271784 @default.
- W2017011135 hasConceptScore W2017011135C203014093 @default.
- W2017011135 hasConceptScore W2017011135C2520015 @default.
- W2017011135 hasConceptScore W2017011135C2776451592 @default.
- W2017011135 hasConceptScore W2017011135C2779122487 @default.
- W2017011135 hasConceptScore W2017011135C2779263046 @default.
- W2017011135 hasConceptScore W2017011135C54355233 @default.
- W2017011135 hasConceptScore W2017011135C62112901 @default.
- W2017011135 hasConceptScore W2017011135C71924100 @default.
- W2017011135 hasConceptScore W2017011135C86803240 @default.
- W2017011135 hasConceptScore W2017011135C95444343 @default.
- W2017011135 hasIssue "11-12" @default.
- W2017011135 hasLocation W20170111351 @default.
- W2017011135 hasLocation W20170111352 @default.
- W2017011135 hasOpenAccess W2017011135 @default.
- W2017011135 hasPrimaryLocation W20170111351 @default.
- W2017011135 hasRelatedWork W1994897684 @default.
- W2017011135 hasRelatedWork W2007813046 @default.
- W2017011135 hasRelatedWork W2013301445 @default.
- W2017011135 hasRelatedWork W2054782702 @default.
- W2017011135 hasRelatedWork W2060924185 @default.
- W2017011135 hasRelatedWork W2134714921 @default.
- W2017011135 hasRelatedWork W2140332254 @default.
- W2017011135 hasRelatedWork W2376173226 @default.
- W2017011135 hasRelatedWork W2748551214 @default.
- W2017011135 hasRelatedWork W2754335455 @default.
- W2017011135 hasVolume "57" @default.
- W2017011135 isParatext "false" @default.
- W2017011135 isRetracted "false" @default.
- W2017011135 magId "2017011135" @default.
- W2017011135 workType "article" @default.