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- W2017012848 abstract "The extent to which schizophrenia (SZ) and psychotic bipolar disorder (BD) represent distinct illnesses has been the focus of debate since Kraepelin and Blueler’s early descriptions of dementia praecox and manic depressive insanity. Their hope, expressed more than a century ago, was that the tools of neuroscience at the time (“clinical observation, the microscope and experimentation”) would lead to improved understanding and treatments of these devastating disorders. In the past century, spectacular advances have occurred at the intersections of neuroscience, psychopharmacology, and genomics. However, few, if any, laboratory tests to inform diagnoses, guide treatments, and monitor response to interventions have graduated from laboratories to clinics. Clinicians still must rely on behavioral observation and careful interview techniques to make inferences about patients’ inner experiences and deductions about the impacted neural systems. Although we have refined indirect clinical assessments for diagnosis and treatment, these methods have evolved relatively little since the late 19th century. Event-Related Potential and Time-Frequency Endophenotypes for Schizophrenia and Psychotic Bipolar DisorderBiological PsychiatryVol. 77Issue 2PreviewThe investigators compared event-related potential (ERP) amplitudes and event-related oscillations across a broad frequency range during an auditory oddball task using a comprehensive analysis approach to describe shared and unique neural auditory processing characteristics among healthy subjects (HP), schizophrenia probands (SZ) and their first-degree relatives, and bipolar disorder I with psychosis probands (BDP) and their first-degree relatives. Full-Text PDF" @default.
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- W2017012848 title "Electroencephalographic Biomarkers of Psychosis: Present and Future" @default.
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- W2017012848 doi "https://doi.org/10.1016/j.biopsych.2014.11.002" @default.
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