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- W2017014342 abstract "Exercise has been demonstrated to potently protect substantia nigra pars compacta (SN) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. One mechanism proposed to account for this neuroprotection is the upregulation of neurotrophic factors. Several neurotrophic factors, including Brain Derived Neurotrophic Factor (BDNF), have been shown to upregulate in response to exercise. In order to determine if exercise-induced neuroprotection is dependent upon BDNF, we compared the neuroprotective effects of voluntary exercise in mice heterozygous for the BDNF gene (BDNF+/−) with strain-matched wild-type (WT) mice. Stereological estimates of SNpc DA neurons from WT mice allowed 90 days exercise via unrestricted running demonstrated complete protection against the MPTP-induced neurotoxicity. However, BDNF+/− mice allowed 90 days of unrestricted exercise were not protected from MPTP-induced SNpc DA neuron loss. Proteomic analysis comparing SN and striatum from 90 day exercised WT and BDNF+/− mice showed differential expression of proteins related to energy regulation, intracellular signaling and trafficking. These results suggest that a full genetic complement of BDNF is critical for the exercise-induced neuroprotection of SNpc DA neurons." @default.
- W2017014342 created "2016-06-24" @default.
- W2017014342 creator A5016515026 @default.
- W2017014342 creator A5031290818 @default.
- W2017014342 creator A5058143660 @default.
- W2017014342 creator A5090470499 @default.
- W2017014342 date "2012-08-17" @default.
- W2017014342 modified "2023-09-25" @default.
- W2017014342 title "Exercise Does Not Protect against MPTP-Induced Neurotoxicity in BDNF Happloinsufficent Mice" @default.
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