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- W2017016029 abstract "In order to avoid modified radical mastectomy a neoadjuvant approach was adopted in our institute for non-inflammatory tumours. From 01/88 to 12/94,238 patients (pts) received as primary chemotherapy 3 different regimens (all doses mg/m 2 ): (l) AVCF/AVCFM, 126 pts (adriamycin 30, vincristine I dl, cyclophosphamide 300, fluorouracil 400 d2–d5 and methotrexate 20 d2 and 4, every 28 d); (2) NEM, 69 pts (navelbine 25, epirubicin 35, methotrexate 20 dl and d8, every 28 d) and (3) TNCF, 43 pts (THP-adria 20, dl–3, navelbine 25 dl and d4, cyclophoshamide 300, fluorouracile 400 dl–d4, every 21 d). In spite of good results with AVCF, the new combinations with navelbine seemed promising (NEM regimen concerned mainly stage II and TNCF stage III tumours): they were all operated for (2) and (3), partially for (l), and showed a progression in pathological complete response rate (pCR). Evaluation comprised 3 methods: clinical (C), echographic (E), mammographic (M). If breast conservation rate (85/85/77%) was quite similar in the 3 regimens, the overall objective response rate (C: 8573/93; E: 75/66/85; M: 58/59/80%) and more importantly pCR (7/16/26%) increased with regimens 2 and 3, with a rise in toxicity with TNCF ( ASCO 1995, abst. 218). If cases where remains only ″ in situ ″ are added, pCR reached 21% with NEM and 28% with TNCF. These navelbine–anthracyclins associations and dose intensity improved pCR, but the impact on survival has to be confirmed." @default.
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- W2017016029 date "1995-11-01" @default.
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- W2017016029 title "53 Comparison of 3 neoadjuvant chemotherapy regimens for operable breast cancer" @default.
- W2017016029 doi "https://doi.org/10.1016/0959-8049(95)95305-p" @default.
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