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- W2017016566 abstract "In the course of a study to produce new long acting local anaesthetics, a number of novel benzylimidazoline derivatives were synthesised and tested for local anaesthetic activity, vasoconstrictor effect and ease of displacement of p-aminoclonidine. The synthesis is shown in Scheme 1. - The synthesised compounds do not exhibit a significant local anaesthetic effect, but display an antihypertensive action with considerable α-2 adrenoceptor binding affinity. Synthese neuer Benzylimidazoline mit blutdrucksenkenden und sedativen Eigenschaften Bei einer Untersuchung mit dem Ziel, langwirkende Lokalanaesthetika synthetisieren, wurden neue Benzylimidazoline hergestellt und auf lokal anaesthetisierende und gefäßverengende Wirkung sowie auf die Fähig geprüft, p-Aminoclonidin aus seiner Bindung zu verdrängen. Die Synth ist in Schema 1 zusammengefaßt. - Die synthetisierten Verbindungen zei keine nennenswerten lokalanaesthetisierenden Eigenschaften, wirken a blutdrucksenkend und besitzen bemerkenswerte Bindungsaffinität zu α-2- Rezeptoren." @default.
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- W2017016566 date "1989-01-01" @default.
- W2017016566 modified "2023-09-23" @default.
- W2017016566 title "Synthesis of Novel Benzylimidazolines Possessing Antihypertensive and Sedative Activity" @default.
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- W2017016566 doi "https://doi.org/10.1002/ardp.19893220702" @default.
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