FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017026310> ?p ?o ?g. }

• W2017026310 abstract "Development of tumour resistance to chemotherapeutic drugs and concerns over their toxic effects has led to the increased use of medicinal herbs or natural products by cancer patients. Strobilanthes crispus is a traditional remedy for many ailments including cancer. Its purported anticancer effects have led to the commercialization of the plant leaves as medicinal herbal tea, although the scientific basis for its use has not been established. We previously reported that a bioactive subfraction of Strobilanthes crispus leaves (SCS) exhibit potent cytotoxic activity against human breast cancer cell lines. The current study investigates the effect of this subfraction on cell death activities induced by the antiestrogen drug, tamoxifen, in estrogen receptor-responsive and nonresponsive breast cancer cells. Cytotoxic activity of SCS and tamoxifen in MCF-7 and MDA-MB-231 human breast cancer cells was determined using lactate dehydrogenase release assay and synergism was evaluated using the CalcuSyn software. Apoptosis was quantified by flow cytometry following Annexin V and propidium iodide staining. Cells were also stained with JC-1 dye to determine changes in the mitochondrial membrane potential. Fluorescence imaging using FAM-FLICA assay detects caspase-8 and caspase-9 activities. DNA damage in the non-malignant breast epithelial cell line, MCF-10A, was evaluated using Comet assay. The combined SCS and tamoxifen treatment displayed strong synergistic inhibition of MCF-7 and MDA-MB-231 cell growth at low doses of the antiestrogen. SCS further promoted the tamoxifen-induced apoptosis that was associated with modulation of mitochondrial membrane potential and activation of caspase-8 and caspase-9, suggesting the involvement of intrinsic and extrinsic signaling pathways. Interestingly, the non-malignant MCF-10A cells displayed no cytotoxicity or DNA damage when treated with either SCS or SCS-tamoxifen combination. The combined use of SCS and lower tamoxifen dose could potentially reduce the side effects/toxicity of the drug. However, further studies are needed to determine the effectiveness and safety of the combination treatment in vivo." @default.
• W2017026310 created "2016-06-24" @default.
• W2017026310 creator A5016608332 @default.
• W2017026310 creator A5023935981 @default.
• W2017026310 creator A5033361403 @default.
• W2017026310 date "2014-07-18" @default.
• W2017026310 modified "2023-10-17" @default.
• W2017026310 title "Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines" @default.
• W2017026310 cites W1520983351 @default.
• W2017026310 cites W1534924266 @default.
• W2017026310 cites W1562190372 @default.
• W2017026310 cites W1964684463 @default.
• W2017026310 cites W1973632800 @default.
• W2017026310 cites W1977552076 @default.
• W2017026310 cites W1977895218 @default.
• W2017026310 cites W1979842763 @default.
• W2017026310 cites W1981576396 @default.
• W2017026310 cites W1984449703 @default.
• W2017026310 cites W1993755672 @default.
• W2017026310 cites W2003939380 @default.
• W2017026310 cites W2005276660 @default.
• W2017026310 cites W2008757142 @default.
• W2017026310 cites W2013008902 @default.
• W2017026310 cites W2015204910 @default.
• W2017026310 cites W2018667424 @default.
• W2017026310 cites W2027616290 @default.
• W2017026310 cites W2029916045 @default.
• W2017026310 cites W2031472508 @default.
• W2017026310 cites W2036705655 @default.
• W2017026310 cites W2039041966 @default.
• W2017026310 cites W2044357365 @default.
• W2017026310 cites W2045563337 @default.
• W2017026310 cites W2049636756 @default.
• W2017026310 cites W2061772210 @default.
• W2017026310 cites W2062853648 @default.
• W2017026310 cites W2067961371 @default.
• W2017026310 cites W2074329998 @default.
• W2017026310 cites W2077945404 @default.
• W2017026310 cites W2083071024 @default.
• W2017026310 cites W2083077527 @default.
• W2017026310 cites W2086802955 @default.
• W2017026310 cites W2100506877 @default.
• W2017026310 cites W2103562758 @default.
• W2017026310 cites W2104260609 @default.
• W2017026310 cites W2114388515 @default.
• W2017026310 cites W2130235602 @default.
• W2017026310 cites W2143583425 @default.
• W2017026310 cites W2146569020 @default.
• W2017026310 cites W2153023759 @default.
• W2017026310 cites W91452638 @default.
• W2017026310 doi "https://doi.org/10.1186/1472-6882-14-252" @default.
• W2017026310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4223515" @default.
• W2017026310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25034326" @default.
• W2017026310 hasPublicationYear "2014" @default.
• W2017026310 type Work @default.
• W2017026310 sameAs 2017026310 @default.
• W2017026310 citedByCount "34" @default.
• W2017026310 countsByYear W20170263102015 @default.
• W2017026310 countsByYear W20170263102016 @default.
• W2017026310 countsByYear W20170263102017 @default.
• W2017026310 countsByYear W20170263102018 @default.
• W2017026310 countsByYear W20170263102019 @default.
• W2017026310 countsByYear W20170263102020 @default.
• W2017026310 countsByYear W20170263102021 @default.
• W2017026310 countsByYear W20170263102022 @default.
• W2017026310 countsByYear W20170263102023 @default.
• W2017026310 crossrefType "journal-article" @default.
• W2017026310 hasAuthorship W2017026310A5016608332 @default.
• W2017026310 hasAuthorship W2017026310A5023935981 @default.
• W2017026310 hasAuthorship W2017026310A5033361403 @default.
• W2017026310 hasBestOaLocation W20170263101 @default.
• W2017026310 hasConcept C109541995 @default.
• W2017026310 hasConcept C121608353 @default.
• W2017026310 hasConcept C126322002 @default.
• W2017026310 hasConcept C185592680 @default.
• W2017026310 hasConcept C190283241 @default.
• W2017026310 hasConcept C2775934118 @default.
• W2017026310 hasConcept C2776067312 @default.
• W2017026310 hasConcept C2777176818 @default.
• W2017026310 hasConcept C2994423619 @default.
• W2017026310 hasConcept C31573885 @default.
• W2017026310 hasConcept C502942594 @default.
• W2017026310 hasConcept C530470458 @default.
• W2017026310 hasConcept C55493867 @default.
• W2017026310 hasConcept C556039675 @default.
• W2017026310 hasConcept C71924100 @default.
• W2017026310 hasConcept C88634738 @default.
• W2017026310 hasConcept C96232424 @default.
• W2017026310 hasConcept C98274493 @default.
• W2017026310 hasConceptScore W2017026310C109541995 @default.
• W2017026310 hasConceptScore W2017026310C121608353 @default.
• W2017026310 hasConceptScore W2017026310C126322002 @default.
• W2017026310 hasConceptScore W2017026310C185592680 @default.
• W2017026310 hasConceptScore W2017026310C190283241 @default.
• W2017026310 hasConceptScore W2017026310C2775934118 @default.
• W2017026310 hasConceptScore W2017026310C2776067312 @default.
• W2017026310 hasConceptScore W2017026310C2777176818 @default.
• W2017026310 hasConceptScore W2017026310C2994423619 @default.
• W2017026310 hasConceptScore W2017026310C31573885 @default.
• W2017026310 hasConceptScore W2017026310C502942594 @default.

• next