FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017028114> ?p ?o ?g. }

• W2017028114 abstract "Nucleoside analogue reverse transcriptase inhibitors are important components in current drug regimens used to treat infection with HIV. Despite the potency of drug combinations that involve two nucleoside reverse transcriptase inhibitors and a non-nucleoside analogue or a protease inhibitor, the emergence of resistance remains a major reason for treatment failure. This article reviews biochemical mechanisms associated with resistance to nucleoside reverse transcriptase inhibitors.The thymidine analogues zidovudine and stavudine select for mutational patterns that facilitate the phosphorolytic excision of literally all available nucleoside reverse transcriptase inhibitors. Major progress has been made in defining genotypes that either support or counteract the reaction. Thymidine analogue-associated mutations were shown to increase rates of excision. In contrast, non-thymidine analogue reverse transcriptase inhibitors select for different mutations, e.g. M184V, L74V, and K65R that diminish the effects of thymidine analogue-associated mutations. Possible underlying biochemical mechanisms are discussed in this review.The non-thymidine analogue-associated mutations M184V, L74V, and K65R show incompatibilities with thymidine-analogue-associated mutations. Maximizing these effects in clinical practice may help delay the emergence of resistance. Together, the clinical and biochemical data validate the excision reaction as a target for the development of novel compounds that interfere with the reaction." @default.
• W2017028114 created "2016-06-24" @default.
• W2017028114 creator A5046764938 @default.
• W2017028114 date "2007-03-01" @default.
• W2017028114 modified "2023-09-24" @default.
• W2017028114 title "Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase" @default.
• W2017028114 cites W1966857068 @default.
• W2017028114 cites W1973711348 @default.
• W2017028114 cites W1979033897 @default.
• W2017028114 cites W1980418635 @default.
• W2017028114 cites W1989189545 @default.
• W2017028114 cites W2005460226 @default.
• W2017028114 cites W2011006965 @default.
• W2017028114 cites W2011144380 @default.
• W2017028114 cites W2015939102 @default.
• W2017028114 cites W2023942953 @default.
• W2017028114 cites W2024731636 @default.
• W2017028114 cites W2028143521 @default.
• W2017028114 cites W2028980458 @default.
• W2017028114 cites W2031074234 @default.
• W2017028114 cites W2033978085 @default.
• W2017028114 cites W2035938088 @default.
• W2017028114 cites W2050647037 @default.
• W2017028114 cites W2051754694 @default.
• W2017028114 cites W2052200516 @default.
• W2017028114 cites W2064576269 @default.
• W2017028114 cites W2084702672 @default.
• W2017028114 cites W2090946777 @default.
• W2017028114 cites W2098890131 @default.
• W2017028114 cites W2103737563 @default.
• W2017028114 cites W2115791564 @default.
• W2017028114 cites W2116234391 @default.
• W2017028114 cites W2119855246 @default.
• W2017028114 cites W2123210495 @default.
• W2017028114 cites W2134308480 @default.
• W2017028114 cites W2144356569 @default.
• W2017028114 cites W2145149448 @default.
• W2017028114 cites W2145502651 @default.
• W2017028114 cites W2146381501 @default.
• W2017028114 cites W2146404328 @default.
• W2017028114 cites W2150487989 @default.
• W2017028114 cites W2151617473 @default.
• W2017028114 cites W2151989745 @default.
• W2017028114 cites W2161976664 @default.
• W2017028114 cites W2168836088 @default.
• W2017028114 cites W2168910994 @default.
• W2017028114 cites W2319798710 @default.
• W2017028114 doi "https://doi.org/10.1097/coh.0b013e3280287a60" @default.
• W2017028114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19372874" @default.
• W2017028114 hasPublicationYear "2007" @default.
• W2017028114 type Work @default.
• W2017028114 sameAs 2017028114 @default.
• W2017028114 citedByCount "5" @default.
• W2017028114 countsByYear W20170281142017 @default.
• W2017028114 countsByYear W20170281142019 @default.
• W2017028114 countsByYear W20170281142021 @default.
• W2017028114 crossrefType "journal-article" @default.
• W2017028114 hasAuthorship W2017028114A5046764938 @default.
• W2017028114 hasConcept C104317684 @default.
• W2017028114 hasConcept C153574943 @default.
• W2017028114 hasConcept C156719811 @default.
• W2017028114 hasConcept C159047783 @default.
• W2017028114 hasConcept C182707283 @default.
• W2017028114 hasConcept C2776543447 @default.
• W2017028114 hasConcept C2777108182 @default.
• W2017028114 hasConcept C2777333352 @default.
• W2017028114 hasConcept C2777351918 @default.
• W2017028114 hasConcept C2779889181 @default.
• W2017028114 hasConcept C2780216070 @default.
• W2017028114 hasConcept C2780727368 @default.
• W2017028114 hasConcept C2909970146 @default.
• W2017028114 hasConcept C3013748606 @default.
• W2017028114 hasConcept C512185932 @default.
• W2017028114 hasConcept C54355233 @default.
• W2017028114 hasConcept C552990157 @default.
• W2017028114 hasConcept C67705224 @default.
• W2017028114 hasConcept C86803240 @default.
• W2017028114 hasConceptScore W2017028114C104317684 @default.
• W2017028114 hasConceptScore W2017028114C153574943 @default.
• W2017028114 hasConceptScore W2017028114C156719811 @default.
• W2017028114 hasConceptScore W2017028114C159047783 @default.
• W2017028114 hasConceptScore W2017028114C182707283 @default.
• W2017028114 hasConceptScore W2017028114C2776543447 @default.
• W2017028114 hasConceptScore W2017028114C2777108182 @default.
• W2017028114 hasConceptScore W2017028114C2777333352 @default.
• W2017028114 hasConceptScore W2017028114C2777351918 @default.
• W2017028114 hasConceptScore W2017028114C2779889181 @default.
• W2017028114 hasConceptScore W2017028114C2780216070 @default.
• W2017028114 hasConceptScore W2017028114C2780727368 @default.
• W2017028114 hasConceptScore W2017028114C2909970146 @default.
• W2017028114 hasConceptScore W2017028114C3013748606 @default.
• W2017028114 hasConceptScore W2017028114C512185932 @default.
• W2017028114 hasConceptScore W2017028114C54355233 @default.
• W2017028114 hasConceptScore W2017028114C552990157 @default.
• W2017028114 hasConceptScore W2017028114C67705224 @default.
• W2017028114 hasConceptScore W2017028114C86803240 @default.
• W2017028114 hasLocation W20170281141 @default.
• W2017028114 hasLocation W20170281142 @default.
• W2017028114 hasOpenAccess W2017028114 @default.
• W2017028114 hasPrimaryLocation W20170281141 @default.

• next