Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017029484> ?p ?o ?g. }
- W2017029484 endingPage "333" @default.
- W2017029484 startingPage "325" @default.
- W2017029484 abstract "Pancreatic cancer studies have shown that inhibition of glycogen synthase kinase-3β (GSK-3β) leads to decreased cancer cell proliferation and survival by abrogating nuclear factor κB (NFκB) activity. In this investigation, various citrus compounds, including flavonoids, phenolic acids, and limonoids, were individually investigated for their inhibitory effects on GSK-3β by using a luminescence assay. Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3β, with 50% inhibitory values of 1.5, 1.9, and 2.0 μM, respectively. Molecular dockings were then performed to determine the potential interactions of each citrus flavonoid with GSK-3β. Luteolin, apigenin, and quercetin were predicted to fit within the binding pocket of GSK-3β with low interaction energies (−76.4, −76.1, and −84.6 kcal·mol−1, respectively) and low complex energies (−718.1, −688.1, and −719.7 kcal·mol−1, respectively). Our results indicate that several citrus flavonoids inhibit GSK-3β activity and suggest that these have potential to suppress the growth of pancreatic tumors." @default.
- W2017029484 created "2016-06-24" @default.
- W2017029484 creator A5013447867 @default.
- W2017029484 creator A5030330976 @default.
- W2017029484 creator A5052457121 @default.
- W2017029484 creator A5053384719 @default.
- W2017029484 creator A5074807289 @default.
- W2017029484 date "2011-04-01" @default.
- W2017029484 modified "2023-10-11" @default.
- W2017029484 title "Citrus Flavonoids Luteolin, Apigenin, and Quercetin Inhibit Glycogen Synthase Kinase-3β Enzymatic Activity by Lowering the Interaction Energy Within the Binding Cavity" @default.
- W2017029484 cites W1563040224 @default.
- W2017029484 cites W1833591189 @default.
- W2017029484 cites W1968935771 @default.
- W2017029484 cites W1972343960 @default.
- W2017029484 cites W1982062664 @default.
- W2017029484 cites W1982958012 @default.
- W2017029484 cites W1983435458 @default.
- W2017029484 cites W1989304353 @default.
- W2017029484 cites W1997224330 @default.
- W2017029484 cites W2000428769 @default.
- W2017029484 cites W2005010788 @default.
- W2017029484 cites W2010556228 @default.
- W2017029484 cites W2027408247 @default.
- W2017029484 cites W2031607563 @default.
- W2017029484 cites W2031896371 @default.
- W2017029484 cites W2038017065 @default.
- W2017029484 cites W2053254886 @default.
- W2017029484 cites W2053372168 @default.
- W2017029484 cites W2057889917 @default.
- W2017029484 cites W2063388716 @default.
- W2017029484 cites W2067392197 @default.
- W2017029484 cites W2071074729 @default.
- W2017029484 cites W2071844432 @default.
- W2017029484 cites W2073128231 @default.
- W2017029484 cites W2073533877 @default.
- W2017029484 cites W2073964987 @default.
- W2017029484 cites W2080864890 @default.
- W2017029484 cites W2083075990 @default.
- W2017029484 cites W2083308747 @default.
- W2017029484 cites W2090867290 @default.
- W2017029484 cites W2109396986 @default.
- W2017029484 cites W2121745326 @default.
- W2017029484 cites W2126244179 @default.
- W2017029484 cites W2131853326 @default.
- W2017029484 cites W2137354244 @default.
- W2017029484 cites W2139032462 @default.
- W2017029484 cites W2145928638 @default.
- W2017029484 cites W2146895097 @default.
- W2017029484 cites W2147421370 @default.
- W2017029484 cites W2155299747 @default.
- W2017029484 cites W2155836103 @default.
- W2017029484 cites W2158734599 @default.
- W2017029484 cites W2160329810 @default.
- W2017029484 cites W2160625740 @default.
- W2017029484 cites W2161182074 @default.
- W2017029484 cites W2168336823 @default.
- W2017029484 cites W2170537843 @default.
- W2017029484 cites W2171992272 @default.
- W2017029484 doi "https://doi.org/10.1089/jmf.2010.0310" @default.
- W2017029484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3123937" @default.
- W2017029484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21443429" @default.
- W2017029484 hasPublicationYear "2011" @default.
- W2017029484 type Work @default.
- W2017029484 sameAs 2017029484 @default.
- W2017029484 citedByCount "91" @default.
- W2017029484 countsByYear W20170294842012 @default.
- W2017029484 countsByYear W20170294842013 @default.
- W2017029484 countsByYear W20170294842014 @default.
- W2017029484 countsByYear W20170294842015 @default.
- W2017029484 countsByYear W20170294842016 @default.
- W2017029484 countsByYear W20170294842017 @default.
- W2017029484 countsByYear W20170294842018 @default.
- W2017029484 countsByYear W20170294842019 @default.
- W2017029484 countsByYear W20170294842020 @default.
- W2017029484 countsByYear W20170294842021 @default.
- W2017029484 countsByYear W20170294842022 @default.
- W2017029484 countsByYear W20170294842023 @default.
- W2017029484 crossrefType "journal-article" @default.
- W2017029484 hasAuthorship W2017029484A5013447867 @default.
- W2017029484 hasAuthorship W2017029484A5030330976 @default.
- W2017029484 hasAuthorship W2017029484A5052457121 @default.
- W2017029484 hasAuthorship W2017029484A5053384719 @default.
- W2017029484 hasAuthorship W2017029484A5074807289 @default.
- W2017029484 hasBestOaLocation W20170294842 @default.
- W2017029484 hasConcept C181199279 @default.
- W2017029484 hasConcept C182996813 @default.
- W2017029484 hasConcept C184235292 @default.
- W2017029484 hasConcept C185592680 @default.
- W2017029484 hasConcept C192118531 @default.
- W2017029484 hasConcept C2776080593 @default.
- W2017029484 hasConcept C2778004101 @default.
- W2017029484 hasConcept C2778609962 @default.
- W2017029484 hasConcept C2779054382 @default.
- W2017029484 hasConcept C2781263971 @default.
- W2017029484 hasConcept C55493867 @default.
- W2017029484 hasConcept C71240020 @default.
- W2017029484 hasConceptScore W2017029484C181199279 @default.
- W2017029484 hasConceptScore W2017029484C182996813 @default.