FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017030003> ?p ?o ?g. }

• W2017030003 endingPage "417" @default.
• W2017030003 startingPage "412" @default.
• W2017030003 abstract "Glucagon secretion is stimulated by fasting and inhibited postprandially, a pattern that mimics the secretory profiles of both ghrelin and GH. We thus hypothesized that glucagon may be a determinant of the changes in circulating ghrelin and GH that occur in relation to meals. The objective of the study was to explore this hypothesis by determining the ghrelin and GH response to a bolus of glucagon or saline in healthy subjects.Nine healthy volunteers, mean age 47 years (range 33-58) and body mass index (BMI) 24 kg/m2 (range 20.9-27.6) were recruited and received either 1 mg glucagon (n = 9) or 1 ml saline (n = 6) subcutaneously on separate days between 0800 and 0830 h after an overnight fast. Venous blood was then sampled at 15-min intervals during the first hour, followed by 30-min intervals up to 4 h for glucose, insulin, GH, cortisol, somatostatin and ghrelin.Mean +/- SE basal ghrelin was 213.1 +/- 34.3 pmol/l and decreased significantly by 15 min after glucagon administration to 179.3 +/- 28 pmol/l (P = 0.01), then remaining suppressed relative to the basal value until 240 min after glucagon. Plasma insulin increased from a basal value of 46.7 +/- 7.7 pmol/l to a peak of 327.1 +/- 54.9 pmol/l (P < 0.0001). There was an inverse statistical relationship between the increase in insulin over the first 120 min and the decrease in ghrelin (P = 0.005), while somatostatin, GH and glucose were not significant contributors to the decrease in ghrelin (P > 0.05). Mean +/- SE basal GH was 7.3 +/- 2.9 microg/l and increased by 150 min after glucagon to a peak of 20.5 +/- 6.8 microg/l (P = 0.006). Changes in neither ghrelin nor glucose were related to the increase in GH (P = 0.7). Saline administration did not produce any significant change in ghrelin, insulin or somatostatin although the expected diurnal reduction in cortisol (P < 0.05) was observed.Our study found no evidence that glucagon stimulates ghrelin secretion in humans and supports the hypothesis that insulin is a negative regulator of ghrelin secretion in the postprandial state. We did not find a negative relationship between endogenous somatostatin and ghrelin despite earlier reports that exogenously administered somatostatin analogues suppress plasma ghrelin. Finally, glucagon-induced GH secretion is not mediated by an increase in plasma ghrelin." @default.
• W2017030003 created "2016-06-24" @default.
• W2017030003 creator A5004138883 @default.
• W2017030003 creator A5004314779 @default.
• W2017030003 creator A5006790865 @default.
• W2017030003 creator A5011832228 @default.
• W2017030003 creator A5063527776 @default.
• W2017030003 creator A5089099525 @default.
• W2017030003 date "2005-10-01" @default.
• W2017030003 modified "2023-10-17" @default.
• W2017030003 title "Prandial regulation of ghrelin secretion in humans: does glucagon contribute to the preprandial increase in circulating ghrelin?" @default.
• W2017030003 cites W120421225 @default.
• W2017030003 cites W1616806865 @default.
• W2017030003 cites W1967827488 @default.
• W2017030003 cites W1969261011 @default.
• W2017030003 cites W1982345662 @default.
• W2017030003 cites W1990436941 @default.
• W2017030003 cites W1998200369 @default.
• W2017030003 cites W2001828991 @default.
• W2017030003 cites W2006011837 @default.
• W2017030003 cites W2011317531 @default.
• W2017030003 cites W2014155696 @default.
• W2017030003 cites W2015178974 @default.
• W2017030003 cites W2021043625 @default.
• W2017030003 cites W2029765733 @default.
• W2017030003 cites W2037889163 @default.
• W2017030003 cites W2042561254 @default.
• W2017030003 cites W2043693077 @default.
• W2017030003 cites W2065908169 @default.
• W2017030003 cites W2076116527 @default.
• W2017030003 cites W2076867259 @default.
• W2017030003 cites W2077356451 @default.
• W2017030003 cites W2079955180 @default.
• W2017030003 cites W2086247606 @default.
• W2017030003 cites W2089133108 @default.
• W2017030003 cites W2092348064 @default.
• W2017030003 cites W2097643786 @default.
• W2017030003 cites W2105573142 @default.
• W2017030003 cites W2106398559 @default.
• W2017030003 cites W2108823659 @default.
• W2017030003 cites W2109459916 @default.
• W2017030003 cites W2112202133 @default.
• W2017030003 cites W2112688443 @default.
• W2017030003 cites W2112759924 @default.
• W2017030003 cites W2113530540 @default.
• W2017030003 cites W2114295425 @default.
• W2017030003 cites W2117095264 @default.
• W2017030003 cites W2128633263 @default.
• W2017030003 cites W2129191053 @default.
• W2017030003 cites W2135340140 @default.
• W2017030003 cites W2146415791 @default.
• W2017030003 cites W2153745306 @default.
• W2017030003 cites W2163865122 @default.
• W2017030003 cites W2441371598 @default.
• W2017030003 cites W4243712281 @default.
• W2017030003 cites W4243801424 @default.
• W2017030003 cites W4245671382 @default.
• W2017030003 cites W4250515828 @default.
• W2017030003 cites W4253127187 @default.
• W2017030003 cites W3141782761 @default.
• W2017030003 doi "https://doi.org/10.1111/j.1365-2265.2005.02357.x" @default.
• W2017030003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16181233" @default.
• W2017030003 hasPublicationYear "2005" @default.
• W2017030003 type Work @default.
• W2017030003 sameAs 2017030003 @default.
• W2017030003 citedByCount "17" @default.
• W2017030003 countsByYear W20170300032013 @default.
• W2017030003 countsByYear W20170300032014 @default.
• W2017030003 countsByYear W20170300032015 @default.
• W2017030003 countsByYear W20170300032016 @default.
• W2017030003 countsByYear W20170300032017 @default.
• W2017030003 countsByYear W20170300032019 @default.
• W2017030003 crossrefType "journal-article" @default.
• W2017030003 hasAuthorship W2017030003A5004138883 @default.
• W2017030003 hasAuthorship W2017030003A5004314779 @default.
• W2017030003 hasAuthorship W2017030003A5006790865 @default.
• W2017030003 hasAuthorship W2017030003A5011832228 @default.
• W2017030003 hasAuthorship W2017030003A5063527776 @default.
• W2017030003 hasAuthorship W2017030003A5089099525 @default.
• W2017030003 hasConcept C126322002 @default.
• W2017030003 hasConcept C134018914 @default.
• W2017030003 hasConcept C185592680 @default.
• W2017030003 hasConcept C2776297358 @default.
• W2017030003 hasConcept C2778024521 @default.
• W2017030003 hasConcept C2778563252 @default.
• W2017030003 hasConcept C2779306644 @default.
• W2017030003 hasConcept C2779357093 @default.
• W2017030003 hasConcept C71315377 @default.
• W2017030003 hasConcept C71924100 @default.
• W2017030003 hasConceptScore W2017030003C126322002 @default.
• W2017030003 hasConceptScore W2017030003C134018914 @default.
• W2017030003 hasConceptScore W2017030003C185592680 @default.
• W2017030003 hasConceptScore W2017030003C2776297358 @default.
• W2017030003 hasConceptScore W2017030003C2778024521 @default.
• W2017030003 hasConceptScore W2017030003C2778563252 @default.
• W2017030003 hasConceptScore W2017030003C2779306644 @default.
• W2017030003 hasConceptScore W2017030003C2779357093 @default.
• W2017030003 hasConceptScore W2017030003C71315377 @default.

• next