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- W2017035597 endingPage "230" @default.
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- W2017035597 abstract "Analysis of mitochondrial DNA (mtDNA) variation has permitted the reconstruction of the ancient migrations of women. This has provided evidence that our species arose in Africa about 150000 years before present (YBP), migrated out of Africa into Asia about 60000 to 70000 YBP and into Europe about 40000 to 50000 YBP, and migrated from Asia and possibly Europe to the Americas about 20000 to 30000 YBP. Although much of the mtDNA variation that exists in modern populations may be selectively neutral, studies of the mildly deleterious mtDNA mutations causing Leber's hereditary optic neuropathy (LHON) have demonstrated that some continent-specific mtDNA lineages are more prone to manifest the clinical symptoms of LHON than others. Hence, all mtDNA lineages are not equal, which may provide insights into the extreme environments that were encountered by our ancient ancestor, and which may be of great importance in understanding the pathophysiology of mitochondrial disease." @default.
- W2017035597 created "2016-06-24" @default.
- W2017035597 creator A5032518195 @default.
- W2017035597 creator A5085274471 @default.
- W2017035597 creator A5089777135 @default.
- W2017035597 date "1999-09-01" @default.
- W2017035597 modified "2023-10-14" @default.
- W2017035597 title "Mitochondrial DNA variation in human evolution and disease" @default.
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- W2017035597 doi "https://doi.org/10.1016/s0378-1119(99)00295-4" @default.
- W2017035597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10570998" @default.
- W2017035597 hasPublicationYear "1999" @default.
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