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- W2017035644 abstract "Mononuclear phagocytes (bone marrow monocyte-derived macrophages, alveolar macrophages, perivascular macrophages, and microglia) are reservoirs and vehicles of dissemination for the human immunodeficiency virus type-1 (HIV-1). How virus alters mononuclear phagocyte immunoregulatory activities to complete its life cycle and influence disease is incompletely understood. In attempts to better understanding the influence of virus on macrophage functions, we used one-dimensional electrophoresis, and liquid chromatography tandem mass spectrometry to analyze the secretome of HIV-1-infected human monocyte-derived macrophages. We identified 110 proteins in culture supernatants of control (uninfected) and virus-infected cells. Differentially expressed cytoskeletal, enzymes, redox, and immunoregulatory protein classes were discovered and validated by Western blot tests. These included, but were not limited to, cystatin C, cystatin B, chitinase 3-like 1 protein, cofilin-1, l-plastin, superoxide dismutase, leukotriene A4 hydrolase, and α-enolase. This study, using a unique proteomics platform, provides novel insights into virus–host cell interactions that likely affect the functional role of macrophages in HIV disease." @default.
- W2017035644 created "2016-06-24" @default.
- W2017035644 creator A5025650388 @default.
- W2017035644 creator A5072903360 @default.
- W2017035644 date "1997-01-01" @default.
- W2017035644 modified "2023-10-17" @default.
- W2017035644 title "HIV1 Nef: the Machiavelli of cellular activation" @default.
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- W2017035644 doi "https://doi.org/10.1016/s0923-2516(97)81915-2" @default.
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