FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017038876> ?p ?o ?g. }

• W2017038876 endingPage "5479" @default.
• W2017038876 startingPage "5465" @default.
• W2017038876 abstract "Focal cortical injuries result in death of cortical neurons and their efferents and ultimately in death or damage of thalamocortical relay (TCR) neurons that project to the affected cortical area. Neurons of the inhibitory reticular thalamic nucleus (nRT) receive excitatory inputs from corticothalamic and thalamocortical axons and are thus denervated by such injuries, yet nRT cells generally survive these insults to a greater degree than TCR cells. nRT cells inhibit TCR cells, regulate thalamocortical transmission, and generate cerebral rhythms including those involved in thalamocortical epilepsies. The survival and reorganization of nRT after cortical injury would determine recovery of thalamocortical circuits after injury. However, the physiological properties and connectivity of the survivors remain unknown. To study possible alterations in nRT neurons, we used the rat photothrombosis model of cortical stroke. Using in vitro patch-clamp recordings at various times after the photothrombotic injury, we show that localized strokes in the somatosensory cortex induce long-term reductions in intrinsic excitability and evoked synaptic excitation of nRT cells by the end of the first week after the injury. We find that nRT neurons in injured rats show (1) decreased membrane input resistance, (2) reduced low-threshold calcium burst responses, and (3) weaker evoked excitatory synaptic responses. Such alterations in nRT cellular excitability could lead to loss of nRT-mediated inhibition in relay nuclei, increased output of surviving TCR cells, and enhanced thalamocortical excitation, which may facilitate recovery of thalamic and cortical sensory circuits. In addition, such changes could be maladaptive, leading to injury-induced epilepsy." @default.
• W2017038876 created "2016-06-24" @default.
• W2017038876 creator A5033400284 @default.
• W2017038876 creator A5076444204 @default.
• W2017038876 creator A5078577221 @default.
• W2017038876 creator A5082613410 @default.
• W2017038876 creator A5083037212 @default.
• W2017038876 date "2010-04-14" @default.
• W2017038876 modified "2023-10-18" @default.
• W2017038876 title "Focal Cortical Infarcts Alter Intrinsic Excitability and Synaptic Excitation in the Reticular Thalamic Nucleus" @default.
• W2017038876 cites W1562752825 @default.
• W2017038876 cites W1589124033 @default.
• W2017038876 cites W1868585274 @default.
• W2017038876 cites W1899597280 @default.
• W2017038876 cites W1927932324 @default.
• W2017038876 cites W1962046274 @default.
• W2017038876 cites W1967740459 @default.
• W2017038876 cites W1969226019 @default.
• W2017038876 cites W1969401787 @default.
• W2017038876 cites W1971545381 @default.
• W2017038876 cites W1972308707 @default.
• W2017038876 cites W1975201915 @default.
• W2017038876 cites W1977074678 @default.
• W2017038876 cites W1979510957 @default.
• W2017038876 cites W1981435269 @default.
• W2017038876 cites W1991424097 @default.
• W2017038876 cites W2000790789 @default.
• W2017038876 cites W2001860569 @default.
• W2017038876 cites W2008365271 @default.
• W2017038876 cites W2009176628 @default.
• W2017038876 cites W2015820903 @default.
• W2017038876 cites W2016291783 @default.
• W2017038876 cites W2023217927 @default.
• W2017038876 cites W2024666274 @default.
• W2017038876 cites W2028473674 @default.
• W2017038876 cites W2030683729 @default.
• W2017038876 cites W2032275093 @default.
• W2017038876 cites W2037400256 @default.
• W2017038876 cites W2047857929 @default.
• W2017038876 cites W2050287820 @default.
• W2017038876 cites W2063045558 @default.
• W2017038876 cites W2064103959 @default.
• W2017038876 cites W2064424149 @default.
• W2017038876 cites W2066049674 @default.
• W2017038876 cites W2067307313 @default.
• W2017038876 cites W2080864593 @default.
• W2017038876 cites W2083571043 @default.
• W2017038876 cites W2088297769 @default.
• W2017038876 cites W2089977258 @default.
• W2017038876 cites W2107670961 @default.
• W2017038876 cites W2109746889 @default.
• W2017038876 cites W2112196515 @default.
• W2017038876 cites W2112927743 @default.
• W2017038876 cites W2114561675 @default.
• W2017038876 cites W2114784445 @default.
• W2017038876 cites W2117496744 @default.
• W2017038876 cites W2120745993 @default.
• W2017038876 cites W2124025293 @default.
• W2017038876 cites W2140651812 @default.
• W2017038876 cites W2149454796 @default.
• W2017038876 cites W2153891187 @default.
• W2017038876 cites W2154871172 @default.
• W2017038876 cites W2162981584 @default.
• W2017038876 cites W2164929734 @default.
• W2017038876 cites W2165340969 @default.
• W2017038876 cites W2167881143 @default.
• W2017038876 cites W2171830917 @default.
• W2017038876 cites W2324979085 @default.
• W2017038876 cites W4229627221 @default.
• W2017038876 cites W4235524857 @default.
• W2017038876 cites W4252604170 @default.
• W2017038876 cites W4298328587 @default.
• W2017038876 doi "https://doi.org/10.1523/jneurosci.5083-09.2010" @default.
• W2017038876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2861582" @default.
• W2017038876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20392967" @default.
• W2017038876 hasPublicationYear "2010" @default.
• W2017038876 type Work @default.
• W2017038876 sameAs 2017038876 @default.
• W2017038876 citedByCount "61" @default.
• W2017038876 countsByYear W20170388762012 @default.
• W2017038876 countsByYear W20170388762013 @default.
• W2017038876 countsByYear W20170388762014 @default.
• W2017038876 countsByYear W20170388762015 @default.
• W2017038876 countsByYear W20170388762016 @default.
• W2017038876 countsByYear W20170388762017 @default.
• W2017038876 countsByYear W20170388762018 @default.
• W2017038876 countsByYear W20170388762019 @default.
• W2017038876 countsByYear W20170388762020 @default.
• W2017038876 countsByYear W20170388762021 @default.
• W2017038876 countsByYear W20170388762022 @default.
• W2017038876 countsByYear W20170388762023 @default.
• W2017038876 crossrefType "journal-article" @default.
• W2017038876 hasAuthorship W2017038876A5033400284 @default.
• W2017038876 hasAuthorship W2017038876A5076444204 @default.
• W2017038876 hasAuthorship W2017038876A5078577221 @default.
• W2017038876 hasAuthorship W2017038876A5082613410 @default.
• W2017038876 hasAuthorship W2017038876A5083037212 @default.
• W2017038876 hasBestOaLocation W20170388761 @default.

• next