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- W2017042783 abstract "Posttranscriptional regulatory programs governing diverse aspects of RNA biology remain largely uncharacterized. Understanding the functional roles of RNA cis-regulatory elements is essential for decoding complex programs that underlie the dynamic regulation of transcript stability, splicing, localization, and translation. Here, we describe a combined experimental/computational technology to reveal a catalog of functional regulatory elements embedded in 3' UTRs of human transcripts. We used a bidirectional reporter system coupled with flow cytometry and high-throughput sequencing to measure the effect of short, noncoding, vertebrate-conserved RNA sequences on transcript stability and translation. Information-theoretic motif analysis of the resulting sequence-to-gene-expression mapping revealed linear and structural RNA cis-regulatory elements that positively and negatively modulate the posttranscriptional fates of human transcripts. This combined experimental/computational strategy can be used to systematically characterize the vast landscape of posttranscriptional regulatory elements controlling physiological and pathological cellular state transitions." @default.
- W2017042783 created "2016-06-24" @default.
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- W2017042783 date "2014-04-01" @default.
- W2017042783 modified "2023-09-24" @default.
- W2017042783 title "Systematic Identification of Regulatory Elements in Conserved 3′ UTRs of Human Transcripts" @default.
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- W2017042783 doi "https://doi.org/10.1016/j.celrep.2014.03.001" @default.
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