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- W2017043287 abstract "Clonidine (CLD) is an imidazoline derivative and α2 adrenergic agonist with anxiolytic properties. It acts at the level of the locus ceruleus via stimulation of presynaptic autoreceptors, reducing sympathetic outflow. Originally introduced perhaps 20 years ago, it was employed as a weak vasodilator in the treatment of hypertension, though it was quickly supplanted by more effective agents, and relegated to the sidelines. It is still prescribed for treatment of peri–menopausal hot flashes, due to its apparent capacity to vaso–stabilize. Applications to child psychiatry did not appear before 1990, when it received some mention in the research literature, albeit as a ‘nonspecific’ application to a variety of psychopathological conditions. At present, its most widely–acclaimed indication is as an adjunct to treatment for Attention–Deficit Hyperactivity Disorder (ADHD), mainly for its properties in promoting sleep, either for primary parasomnias or those induced by stimulant treatment. There have been only sporadic citations in the research literature to clonidine’s utility in the treatment of Posttraumatic Stress Disorder (PTSD). Research into its capacity to ameliorate post–traumatic features was slowed by reports of its mediocre effects upon chronic PTSD, and its application to adults, as opposed to children. Several interesting reports however, yielded tantalizing glimpses into its potential for special application to childhood PTSD. Notably, in studies of non–specific anxiety, growth hormone (GH) response was found not to be blunted by CLD challenge—the opposite effect to that observed in adults—which led authors to speculate that adrenergic post–synaptic down regulation is not a feature of childhood anxiety, and further, that early intervention might prevent the development of down–regulation, which itself may be persistent. This would seem to suggest the possibility of a “window of opportunity” for pharmacologic treatment following traumatic exposure, in which noradrenergic outflow, prompted by exaggerated threat-estimate’s maximal, yet permanent changes in the form of persistent perhaps permanent down regulation of receptors has not yet occurred." @default.
- W2017043287 created "2016-06-24" @default.
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- W2017043287 date "2003-12-01" @default.
- W2017043287 modified "2023-10-18" @default.
- W2017043287 title "Characteristics of Clonidine Responders in Childhood PTSD: Its Possible Use in Acute Trauma" @default.
- W2017043287 doi "https://doi.org/10.1521/capn.8.8.6.27932" @default.
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