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- W2017046158 abstract "0756 PURPOSE: To assess the independent and synergistic effects of oral contraceptive (OC) use on bone mineral density (BMD) and bone mechanical stiffness (EI) in college-aged females after unilateral isokinetic resistance training. METHODS: Forty six females (age 20 ± 1.4 yr, height 163.8 ± 6.2cm, weight 58.9 ± 8.6kg, %fat 27.9 ± 4.8) were categorized as OC users (OC, N = 22) or not (NOC, N = 24) and participated in 32 weeks (3 d/wk) of unilateral arm and leg training, angular velocity 60°/s, using isokinetic dynamometers. BMD and EIMRTA were assessed using dual-energy x-ray absorptiometry (DXA) and mechanical response tissue analysis (MRTA), respectively. RESULTS: Leg and arm muscular strength increased by 16% and 15%, respectively (P < 0.001), beyond the pre- to post-training changes observed in the control limbs. Muscular strength gains were not associated with any consistent changes in either leg or arm EIMRTA, nor did groups using or not using OC respond differently. Both BMD of the tibia for the control leg and for the total body increased by small but significant amounts (1.4% and 0.4%, respectively; P <0.05) in the NOC group. The OC group showed no increase in these two measures, suggesting a potential suppressive effect of OC on bone mass accumulation in these skeletally immature females. However, BMD increased in the ulna bilaterally (P <0.01) and in the total hip of the trained leg only (P <0.05), regardless of OC use. CONCLUSION: These results suggest that oral contraceptives may limit attainment of total body peak bone mass in young adult females. Variable effects on appendicular bone were inconsistent in both control and regions of interest for assessing isokinetic training. Further studies are needed to determine the interactive effects of OC use and isokinetic resistance training on measures of bone strength. Supporting agency: United States Army Medical Research and Materiel Command, Grant #DAMD17-00-1-0114" @default.
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- W2017046158 date "2004-05-01" @default.
- W2017046158 modified "2023-09-25" @default.
- W2017046158 title "Influence of Oral Contraceptives on Bone Adaptations to Isokinetic Strength Training in Young Women" @default.
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- W2017046158 doi "https://doi.org/10.1097/00005768-200405001-00505" @default.
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