FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017046166> ?p ?o ?g. }

• W2017046166 abstract "Abstract Background Thiamine (vitamin B1) deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the central nervous system (CNS). TD in animals has been used to model aging-associated neurodegeneration in the brain. The mechanisms of TD-induced neuron death are complex, and it is likely multiple mechanisms interplay and contribute to the action of TD. In this study, we demonstrated that TD significantly increased intracellular calcium concentrations [Ca 2+ ] i in cultured cortical neurons. Results TD drastically potentiated AMPA-triggered calcium influx and inhibited pre-mRNA editing of GluR2, a Ca 2+ -permeable subtype of AMPA receptors. The Ca 2+ permeability of GluR2 is regulated by RNA editing at the Q/R site. Edited GluR2 (R) subunits form Ca 2+ -impermeable channels, whereas unedited GluR2 (Q) channels are permeable to Ca 2+ flow. TD inhibited Q/R editing of GluR2 and increased the ratio of unedited GluR2. The Q/R editing of GluR2 is mediated by adenosine deaminase acting on RNA 2 (ADAR2). TD selectively decreased ADAR2 expression and its self-editing ability without affecting ADAR1 in cultured neurons and in the brain tissue. Over-expression of ADAR2 reduced AMPA-mediated rise of [Ca 2+ ] i and protected cortical neurons against TD-induced cytotoxicity, whereas down-regulation of ADAR2 increased AMPA-elicited Ca 2+ influx and exacerbated TD-induced death of cortical neurons. Conclusions Our findings suggest that TD-induced neuronal damage may be mediated by the modulation of ADAR2-dependent RNA Editing of GluR2." @default.
• W2017046166 created "2016-06-24" @default.
• W2017046166 creator A5013922292 @default.
• W2017046166 creator A5027969363 @default.
• W2017046166 creator A5041424398 @default.
• W2017046166 creator A5045793001 @default.
• W2017046166 creator A5052936351 @default.
• W2017046166 creator A5060002817 @default.
• W2017046166 creator A5069358093 @default.
• W2017046166 creator A5070826161 @default.
• W2017046166 creator A5077683938 @default.
• W2017046166 creator A5077779346 @default.
• W2017046166 creator A5078004519 @default.
• W2017046166 creator A5079536806 @default.
• W2017046166 creator A5090256693 @default.
• W2017046166 date "2010-11-27" @default.
• W2017046166 modified "2023-10-03" @default.
• W2017046166 title "ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics" @default.
• W2017046166 cites W1269262402 @default.
• W2017046166 cites W1509704113 @default.
• W2017046166 cites W1584917605 @default.
• W2017046166 cites W1765185969 @default.
• W2017046166 cites W1948270772 @default.
• W2017046166 cites W1970400951 @default.
• W2017046166 cites W1970941517 @default.
• W2017046166 cites W1981947870 @default.
• W2017046166 cites W1982398040 @default.
• W2017046166 cites W1986101977 @default.
• W2017046166 cites W1990286087 @default.
• W2017046166 cites W1992604303 @default.
• W2017046166 cites W1992970643 @default.
• W2017046166 cites W1999968276 @default.
• W2017046166 cites W2000352386 @default.
• W2017046166 cites W2008476211 @default.
• W2017046166 cites W2012956176 @default.
• W2017046166 cites W2014127990 @default.
• W2017046166 cites W2018793883 @default.
• W2017046166 cites W2023031512 @default.
• W2017046166 cites W2027429364 @default.
• W2017046166 cites W2031153226 @default.
• W2017046166 cites W2036565829 @default.
• W2017046166 cites W2043387126 @default.
• W2017046166 cites W2046641567 @default.
• W2017046166 cites W2048984862 @default.
• W2017046166 cites W2051084778 @default.
• W2017046166 cites W2054086992 @default.
• W2017046166 cites W2062918974 @default.
• W2017046166 cites W2065797404 @default.
• W2017046166 cites W2067493668 @default.
• W2017046166 cites W2074385487 @default.
• W2017046166 cites W2074562954 @default.
• W2017046166 cites W2075684020 @default.
• W2017046166 cites W2077703139 @default.
• W2017046166 cites W2078108612 @default.
• W2017046166 cites W2080203024 @default.
• W2017046166 cites W2083370339 @default.
• W2017046166 cites W2083443360 @default.
• W2017046166 cites W2090872672 @default.
• W2017046166 cites W2090937100 @default.
• W2017046166 cites W2094767283 @default.
• W2017046166 cites W2096887290 @default.
• W2017046166 cites W2098365915 @default.
• W2017046166 cites W2101193008 @default.
• W2017046166 cites W2110358620 @default.
• W2017046166 cites W2119067306 @default.
• W2017046166 cites W2124727655 @default.
• W2017046166 cites W2141260882 @default.
• W2017046166 cites W2144671795 @default.
• W2017046166 cites W2145373866 @default.
• W2017046166 cites W2148632242 @default.
• W2017046166 cites W2159079989 @default.
• W2017046166 cites W2161048703 @default.
• W2017046166 cites W2165064047 @default.
• W2017046166 cites W2326087522 @default.
• W2017046166 cites W2808327857 @default.
• W2017046166 doi "https://doi.org/10.1186/1750-1326-5-54" @default.
• W2017046166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3006372" @default.
• W2017046166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21110885" @default.
• W2017046166 hasPublicationYear "2010" @default.
• W2017046166 type Work @default.
• W2017046166 sameAs 2017046166 @default.
• W2017046166 citedByCount "27" @default.
• W2017046166 countsByYear W20170461662012 @default.
• W2017046166 countsByYear W20170461662013 @default.
• W2017046166 countsByYear W20170461662014 @default.
• W2017046166 countsByYear W20170461662015 @default.
• W2017046166 countsByYear W20170461662016 @default.
• W2017046166 countsByYear W20170461662017 @default.
• W2017046166 countsByYear W20170461662018 @default.
• W2017046166 countsByYear W20170461662019 @default.
• W2017046166 countsByYear W20170461662020 @default.
• W2017046166 countsByYear W20170461662021 @default.
• W2017046166 countsByYear W20170461662022 @default.
• W2017046166 countsByYear W20170461662023 @default.
• W2017046166 crossrefType "journal-article" @default.
• W2017046166 hasAuthorship W2017046166A5013922292 @default.
• W2017046166 hasAuthorship W2017046166A5027969363 @default.
• W2017046166 hasAuthorship W2017046166A5041424398 @default.
• W2017046166 hasAuthorship W2017046166A5045793001 @default.
• W2017046166 hasAuthorship W2017046166A5052936351 @default.

• next