FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017052005> ?p ?o ?g. }

• W2017052005 endingPage "e5233" @default.
• W2017052005 startingPage "e5233" @default.
• W2017052005 abstract "There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors. Using an advanced living polymerization technique, the reversible addition-fragmentation chain transfer (RAFT), we conjugated the aminobisphosphonate alendronate (ALN), and the potent anti-angiogenic agent TNP-470 with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer through a Glycine-Glycine-Proline-Norleucine linker, cleaved by cathepsin K, a cysteine protease overexpressed at resorption sites in bone tissues. In this approach, dual targeting is achieved. Passive accumulation is possible due to the increase in molecular weight following polymer conjugation of the drugs, thus extravasating from the tumor leaky vessels and not from normal healthy vessels. Active targeting to the calcified tissues is achieved by ALN's affinity to bone mineral.The anti-angiogenic and antitumor potency of HPMA copolymer-ALN-TNP-470 conjugate was evaluated both in vitro and in vivo. We show that free and conjugated ALN-TNP-470 have synergistic anti-angiogenic and antitumor activity by inhibiting proliferation, migration and capillary-like tube formation of endothelial and human osteosarcoma cells in vitro. Evaluation of anti-angiogenic, antitumor activity and body distribution of HPMA copolymer-ALN-TNP-470 conjugate was performed on severe combined immunodeficiency (SCID) male mice inoculated with mCherry-labeled MG-63-Ras human osteosarcoma and by modified Miles permeability assay. Our targeted bi-specific conjugate reduced VEGF-induced vascular hyperpermeability by 92% and remarkably inhibited osteosarcoma growth in mice by 96%.This is the first report to describe a new concept of a narrowly-dispersed combined polymer therapeutic designed to target both tumor and endothelial compartments of bone metastases and calcified neoplasms at a single administration. This new approach of co-delivery of two synergistic drugs may have clinical utility as a potential therapy for angiogenesis-dependent cancers such as osteosarcoma and bone metastases." @default.
• W2017052005 created "2016-06-24" @default.
• W2017052005 creator A5007440695 @default.
• W2017052005 creator A5007941824 @default.
• W2017052005 creator A5008462309 @default.
• W2017052005 creator A5049307370 @default.
• W2017052005 creator A5061202040 @default.
• W2017052005 creator A5070242893 @default.
• W2017052005 creator A5088545148 @default.
• W2017052005 date "2009-04-21" @default.
• W2017052005 modified "2023-10-17" @default.
• W2017052005 title "Targeting Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics" @default.
• W2017052005 cites W1596072784 @default.
• W2017052005 cites W1948868238 @default.
• W2017052005 cites W1966463670 @default.
• W2017052005 cites W1971230694 @default.
• W2017052005 cites W1978139448 @default.
• W2017052005 cites W1992212956 @default.
• W2017052005 cites W1996177349 @default.
• W2017052005 cites W2000144084 @default.
• W2017052005 cites W2006202974 @default.
• W2017052005 cites W2006878588 @default.
• W2017052005 cites W2008636068 @default.
• W2017052005 cites W2010435021 @default.
• W2017052005 cites W2010486222 @default.
• W2017052005 cites W2012852444 @default.
• W2017052005 cites W2020558434 @default.
• W2017052005 cites W2032215744 @default.
• W2017052005 cites W2034447474 @default.
• W2017052005 cites W2034965201 @default.
• W2017052005 cites W2036759587 @default.
• W2017052005 cites W2040922374 @default.
• W2017052005 cites W2041402315 @default.
• W2017052005 cites W2044030495 @default.
• W2017052005 cites W2044268096 @default.
• W2017052005 cites W2044332600 @default.
• W2017052005 cites W2045023599 @default.
• W2017052005 cites W2048224440 @default.
• W2017052005 cites W2051499339 @default.
• W2017052005 cites W2054803078 @default.
• W2017052005 cites W2055838505 @default.
• W2017052005 cites W2062012969 @default.
• W2017052005 cites W2069754084 @default.
• W2017052005 cites W2076424556 @default.
• W2017052005 cites W2076765938 @default.
• W2017052005 cites W2077304538 @default.
• W2017052005 cites W2079313855 @default.
• W2017052005 cites W2084071045 @default.
• W2017052005 cites W2084792872 @default.
• W2017052005 cites W2088796820 @default.
• W2017052005 cites W2089961321 @default.
• W2017052005 cites W2092483187 @default.
• W2017052005 cites W2096659441 @default.
• W2017052005 cites W2100593186 @default.
• W2017052005 cites W2101624026 @default.
• W2017052005 cites W2112431117 @default.
• W2017052005 cites W2119405093 @default.
• W2017052005 cites W2130392240 @default.
• W2017052005 cites W2137841367 @default.
• W2017052005 cites W2139175722 @default.
• W2017052005 cites W2139780910 @default.
• W2017052005 cites W2145786098 @default.
• W2017052005 cites W2147513976 @default.
• W2017052005 cites W2147640616 @default.
• W2017052005 cites W2152179330 @default.
• W2017052005 cites W2155393958 @default.
• W2017052005 cites W2163048481 @default.
• W2017052005 cites W2164327861 @default.
• W2017052005 cites W2168100008 @default.
• W2017052005 cites W2242768312 @default.
• W2017052005 cites W2319962899 @default.
• W2017052005 cites W4244004143 @default.
• W2017052005 cites W4254572210 @default.
• W2017052005 doi "https://doi.org/10.1371/journal.pone.0005233" @default.
• W2017052005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2667669" @default.
• W2017052005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19381291" @default.
• W2017052005 hasPublicationYear "2009" @default.
• W2017052005 type Work @default.
• W2017052005 sameAs 2017052005 @default.
• W2017052005 citedByCount "105" @default.
• W2017052005 countsByYear W20170520052012 @default.
• W2017052005 countsByYear W20170520052013 @default.
• W2017052005 countsByYear W20170520052014 @default.
• W2017052005 countsByYear W20170520052015 @default.
• W2017052005 countsByYear W20170520052016 @default.
• W2017052005 countsByYear W20170520052017 @default.
• W2017052005 countsByYear W20170520052018 @default.
• W2017052005 countsByYear W20170520052019 @default.
• W2017052005 countsByYear W20170520052020 @default.
• W2017052005 countsByYear W20170520052021 @default.
• W2017052005 countsByYear W20170520052022 @default.
• W2017052005 countsByYear W20170520052023 @default.
• W2017052005 crossrefType "journal-article" @default.
• W2017052005 hasAuthorship W2017052005A5007440695 @default.
• W2017052005 hasAuthorship W2017052005A5007941824 @default.
• W2017052005 hasAuthorship W2017052005A5008462309 @default.
• W2017052005 hasAuthorship W2017052005A5049307370 @default.
• W2017052005 hasAuthorship W2017052005A5061202040 @default.

• next