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• W2017055786 abstract "Background By using Doppler echocardiography, we determined the normal distribution of human fetal combined cardiac output (CCO) from the left and right ventricles. We also established weight-indexed pulmonary and systemic vascular resistances (R Pi and R Si , respectively) and changes during the second half of pregnancy. Methods and Results Blood flows at the aortic and pulmonary valve annuli (LVCO and RVCO, respectively), right and left pulmonary arteries (Q P ), and ductus arteriosus (Q DA ) were calculated in 63 normal fetuses. Foramen ovale blood flow (Q FO =LVCO−Q P ) was estimated. From 20 to 30 weeks of gestation, the proportion of Q P of the CCO increased (from 13% to 25%, P <.001), while the proportion of Q FO decreased (from 34% to 18%, P <.001). After 30 weeks, the proportions of Q P and Q FO were unchanged. At 38 weeks, the proportion of RVCO (60%) was higher ( P <.05) than that of LVCO (40%). The proportion of Q DA did not change significantly. The correlation between RVCO calculated from blood flow through the pulmonary valve and from Q DA and Q P was good ( r =.97, P <.0001). R Pi ( P <.001) decreased from 20 to 30 weeks of gestation. From 30 to 38 weeks, R Pi increased ( P <.0001). R Si increased ( P <.001) from 20 to 38 weeks. The ratio of R Pi to R Si decreased ( P <.01) from 20 to 30 weeks and later remained unchanged. Conclusions The human fetal pulmonary circulation has an important role in the distribution of cardiac output." @default.
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• W2017055786 date "1996-09-01" @default.
• W2017055786 modified "2023-10-15" @default.
• W2017055786 title "Role of the Pulmonary Circulation in the Distribution of Human Fetal Cardiac Output During the Second Half of Pregnancy" @default.
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• W2017055786 doi "https://doi.org/10.1161/01.cir.94.5.1068" @default.
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