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• W2017058661 abstract "ObjectiveWe have experienced successful pregnancies and births with calcium ionophore (A23187) and strontium chloride (SrCl2) oocyte activation (OA) in patients with low fertilization rate (< 30%) following intracytoplasmic sperm injection (ICSI).DesignRetrospective study.Materials and MethodsSubjects of 85 couples were selected from patients who had unsuccessful ICSI treatments between April 2004 and October 2010 at our clinic and it was divided into two groups (Study1and 2). 50patients were in the A23187 group, and 35 patients were in the SrCl2 group. And we compared the two clinical results with or without OA. We compared the development and health of babies born after OA.ResultsComparing the results without or with A23187, the results were as follows: fertilization rates, 20.9% (50/239) vs. 62.5% (170/272): P<0.01; cleavage, 24.7% (18/73) vs. 42.5% (60/141): P<0.01; blastocyst rates, 25.9% (14/54) vs. 39.4% (39/99): NS; clinical pregnancy rates, 0% (0/20) vs. 20.3% (14/69): NS; and miscarriage rates, 0% (0/0) vs. 28.6% (4/14): NS. Comparing the results without and with SrCl2, the results were as follows: fertilizationrates, 24.7% (48/194) vs. 57.9% (147/254): P<0.01; cleavage, 12.0% (6/50) vs. 23.6% (29/123): P<0.05; blastocyst rates, 6.7% (2/30) vs. 41.2% (40/97): P<0.01; clinical pregnancy rates, 0% vs. 25.0% (11/45): NS; and miscarriage rates, 0% (0/0) vs. 27.3% (3/11): NS.10 babies from 9 couples were born after A23187 OA, and 12 babies from 9 patients were born after SrCl2 OA. The developmental characteristics of infants showed no significant difference between babies born after ICSI with and without OA.ConclusionArtificial OA using A23187 or SrCl2 is beneficial to patients with low or no fertility. This study showed that the OA does not adversely affect the growth or health of babies. Further studies are needed to confirm the safety of OA as with all assisted reproductive technology treatment. ObjectiveWe have experienced successful pregnancies and births with calcium ionophore (A23187) and strontium chloride (SrCl2) oocyte activation (OA) in patients with low fertilization rate (< 30%) following intracytoplasmic sperm injection (ICSI). We have experienced successful pregnancies and births with calcium ionophore (A23187) and strontium chloride (SrCl2) oocyte activation (OA) in patients with low fertilization rate (< 30%) following intracytoplasmic sperm injection (ICSI). DesignRetrospective study. Retrospective study. Materials and MethodsSubjects of 85 couples were selected from patients who had unsuccessful ICSI treatments between April 2004 and October 2010 at our clinic and it was divided into two groups (Study1and 2). 50patients were in the A23187 group, and 35 patients were in the SrCl2 group. And we compared the two clinical results with or without OA. We compared the development and health of babies born after OA. Subjects of 85 couples were selected from patients who had unsuccessful ICSI treatments between April 2004 and October 2010 at our clinic and it was divided into two groups (Study1and 2). 50patients were in the A23187 group, and 35 patients were in the SrCl2 group. And we compared the two clinical results with or without OA. We compared the development and health of babies born after OA. ResultsComparing the results without or with A23187, the results were as follows: fertilization rates, 20.9% (50/239) vs. 62.5% (170/272): P<0.01; cleavage, 24.7% (18/73) vs. 42.5% (60/141): P<0.01; blastocyst rates, 25.9% (14/54) vs. 39.4% (39/99): NS; clinical pregnancy rates, 0% (0/20) vs. 20.3% (14/69): NS; and miscarriage rates, 0% (0/0) vs. 28.6% (4/14): NS. Comparing the results without and with SrCl2, the results were as follows: fertilizationrates, 24.7% (48/194) vs. 57.9% (147/254): P<0.01; cleavage, 12.0% (6/50) vs. 23.6% (29/123): P<0.05; blastocyst rates, 6.7% (2/30) vs. 41.2% (40/97): P<0.01; clinical pregnancy rates, 0% vs. 25.0% (11/45): NS; and miscarriage rates, 0% (0/0) vs. 27.3% (3/11): NS.10 babies from 9 couples were born after A23187 OA, and 12 babies from 9 patients were born after SrCl2 OA. The developmental characteristics of infants showed no significant difference between babies born after ICSI with and without OA. Comparing the results without or with A23187, the results were as follows: fertilization rates, 20.9% (50/239) vs. 62.5% (170/272): P<0.01; cleavage, 24.7% (18/73) vs. 42.5% (60/141): P<0.01; blastocyst rates, 25.9% (14/54) vs. 39.4% (39/99): NS; clinical pregnancy rates, 0% (0/20) vs. 20.3% (14/69): NS; and miscarriage rates, 0% (0/0) vs. 28.6% (4/14): NS. Comparing the results without and with SrCl2, the results were as follows: fertilizationrates, 24.7% (48/194) vs. 57.9% (147/254): P<0.01; cleavage, 12.0% (6/50) vs. 23.6% (29/123): P<0.05; blastocyst rates, 6.7% (2/30) vs. 41.2% (40/97): P<0.01; clinical pregnancy rates, 0% vs. 25.0% (11/45): NS; and miscarriage rates, 0% (0/0) vs. 27.3% (3/11): NS. 10 babies from 9 couples were born after A23187 OA, and 12 babies from 9 patients were born after SrCl2 OA. The developmental characteristics of infants showed no significant difference between babies born after ICSI with and without OA. ConclusionArtificial OA using A23187 or SrCl2 is beneficial to patients with low or no fertility. This study showed that the OA does not adversely affect the growth or health of babies. Further studies are needed to confirm the safety of OA as with all assisted reproductive technology treatment. Artificial OA using A23187 or SrCl2 is beneficial to patients with low or no fertility. This study showed that the OA does not adversely affect the growth or health of babies. Further studies are needed to confirm the safety of OA as with all assisted reproductive technology treatment." @default.
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• W2017058661 title "Effect of oocyte activation by calcium ionophore A23187 or strontium chloride in patients with low fertilization rates and follow-up of babies" @default.
• W2017058661 doi "https://doi.org/10.1016/j.fertnstert.2011.07.634" @default.
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