FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017059637> ?p ?o ?g. }

• W2017059637 endingPage "7093" @default.
• W2017059637 startingPage "7075" @default.
• W2017059637 abstract "Phosphonic acid (PA) thyroid hormone receptor (TR) agonists were synthesized to exploit the poor distribution of PA-based drugs to extrahepatic tissues and thereby to improve the therapeutic index. Nine PAs showed excellent TR binding affinities (TRbeta(1), K(i) < 10 nM), and most of them demonstrated significant cholesterol lowering effects in a cholesterol-fed rat (CFR) model. Unlike the corresponding carboxylic acid analogue and T(3), PA 22c demonstrated liver-selective effects by inducing maximal mitochondrial glycerol-3-phosphate dehydrogenase activity in rat liver while having no effect in the heart. Because of the low oral bioavailability of PA 22c, a series of prodrugs was synthesized and screened for oral efficacy in the CFR assay. The liver-activated cyclic 1-(3-chlorophenyl)-1,3-propanyl prodrug (MB07811) showed potent lipid lowering activity in the CFR (ED(50) 0.4 mg/kg, po) and good oral bioavailability (40%, rat) and was selected for development for the treatment of hypercholesterolemia." @default.
• W2017059637 created "2016-06-24" @default.
• W2017059637 creator A5006585781 @default.
• W2017059637 creator A5013790766 @default.
• W2017059637 creator A5018337886 @default.
• W2017059637 creator A5031461345 @default.
• W2017059637 creator A5034218946 @default.
• W2017059637 creator A5035272925 @default.
• W2017059637 creator A5037344891 @default.
• W2017059637 creator A5041499921 @default.
• W2017059637 creator A5045048134 @default.
• W2017059637 creator A5046826188 @default.
• W2017059637 creator A5056552291 @default.
• W2017059637 creator A5071771766 @default.
• W2017059637 creator A5081061131 @default.
• W2017059637 creator A5085770521 @default.
• W2017059637 date "2008-11-01" @default.
• W2017059637 modified "2023-10-03" @default.
• W2017059637 title "Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic Acid Thyroid Hormone Receptor Agonists and Their Prodrugs" @default.
• W2017059637 cites W124544113 @default.
• W2017059637 cites W1485967434 @default.
• W2017059637 cites W1581438722 @default.
• W2017059637 cites W1963650290 @default.
• W2017059637 cites W1968749056 @default.
• W2017059637 cites W1970832653 @default.
• W2017059637 cites W1971306088 @default.
• W2017059637 cites W1972498462 @default.
• W2017059637 cites W1972712571 @default.
• W2017059637 cites W1985760728 @default.
• W2017059637 cites W1988920005 @default.
• W2017059637 cites W1998196797 @default.
• W2017059637 cites W1998466191 @default.
• W2017059637 cites W2002337438 @default.
• W2017059637 cites W2009624446 @default.
• W2017059637 cites W2011277263 @default.
• W2017059637 cites W2011693511 @default.
• W2017059637 cites W2012928524 @default.
• W2017059637 cites W2015005155 @default.
• W2017059637 cites W2019804360 @default.
• W2017059637 cites W2020125297 @default.
• W2017059637 cites W2022727131 @default.
• W2017059637 cites W2025057112 @default.
• W2017059637 cites W2027342230 @default.
• W2017059637 cites W2029473474 @default.
• W2017059637 cites W2039457120 @default.
• W2017059637 cites W2042163543 @default.
• W2017059637 cites W2050758709 @default.
• W2017059637 cites W2052440137 @default.
• W2017059637 cites W2054953645 @default.
• W2017059637 cites W2055080638 @default.
• W2017059637 cites W2056991025 @default.
• W2017059637 cites W2057924974 @default.
• W2017059637 cites W2058859643 @default.
• W2017059637 cites W2059695404 @default.
• W2017059637 cites W2062370426 @default.
• W2017059637 cites W2079236286 @default.
• W2017059637 cites W2088551222 @default.
• W2017059637 cites W2091455514 @default.
• W2017059637 cites W2103007873 @default.
• W2017059637 cites W2106343349 @default.
• W2017059637 cites W2111243309 @default.
• W2017059637 cites W2112658297 @default.
• W2017059637 cites W2115905649 @default.
• W2017059637 cites W2119236594 @default.
• W2017059637 cites W2130586216 @default.
• W2017059637 cites W2133839930 @default.
• W2017059637 cites W2137415681 @default.
• W2017059637 cites W2141742236 @default.
• W2017059637 cites W2142640185 @default.
• W2017059637 cites W2151068695 @default.
• W2017059637 cites W2152086330 @default.
• W2017059637 cites W2154456365 @default.
• W2017059637 cites W2160166542 @default.
• W2017059637 cites W2164721528 @default.
• W2017059637 cites W2318370287 @default.
• W2017059637 cites W2325705904 @default.
• W2017059637 cites W2480766118 @default.
• W2017059637 cites W2608539973 @default.
• W2017059637 cites W2951646900 @default.
• W2017059637 doi "https://doi.org/10.1021/jm800824d" @default.
• W2017059637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18975928" @default.
• W2017059637 hasPublicationYear "2008" @default.
• W2017059637 type Work @default.
• W2017059637 sameAs 2017059637 @default.
• W2017059637 citedByCount "47" @default.
• W2017059637 countsByYear W20170596372012 @default.
• W2017059637 countsByYear W20170596372013 @default.
• W2017059637 countsByYear W20170596372014 @default.
• W2017059637 countsByYear W20170596372015 @default.
• W2017059637 countsByYear W20170596372016 @default.
• W2017059637 countsByYear W20170596372017 @default.
• W2017059637 countsByYear W20170596372018 @default.
• W2017059637 countsByYear W20170596372019 @default.
• W2017059637 countsByYear W20170596372020 @default.
• W2017059637 countsByYear W20170596372021 @default.
• W2017059637 countsByYear W20170596372022 @default.
• W2017059637 countsByYear W20170596372023 @default.
• W2017059637 crossrefType "journal-article" @default.

• next