FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017059781> ?p ?o ?g. }

• W2017059781 endingPage "1704" @default.
• W2017059781 startingPage "1695" @default.
• W2017059781 abstract "Between April 1977, and August 1980, the Children's Cancer Study Group (CCSG) conducted a clinical trial of childhood non-Hodgkin's lymphoma (NHL), randomizing 256 patients to one of two treatment regimens. A 4-drug regimen (regimen 1, modified cyclophosphamide, Oncorin [vincristine], methotrexate, prednisone [COMP] ) was compared with a 10-drug regimen (regimen 2, modified LSA2-L2). Using the Rappaport classification, the review pathologist diagnosed the 213 evaluable tissue specimens as follows: lymphoblastic (LC), 73; Burkitt's tumor (BT), 40; undifferentiated non-Burkitt's type (NB), 67; large cell or histiocytic lymphoma (HI), 29; and other types (OT), 4. Concurrence in classification between the review and institutional pathologists was poor when using the above four categories; however, concurrence was 88% between the review pathologist and other hematopathologists, and 99% when classifying the specimens as lymphoblastic or nonlymphoblastic. For patients with nonlocalized disease, this randomized controlled study demonstrated a new important correlation of histopathology with the effectiveness of treatment. When analyzed without stratification into lymphoblastic and nonlymphoblastic types, the two regimens showed identical relapse free survival (RFS) curves for patients with nonlocalized involvement. However, when patients were stratified according to histologic classification, regimen 2 was superior to regimen 1 for patients with lymphoblastic lymphoma, achieving 74% RFS at 30 months compared to 31% for regimen 1 (P = 0.001). Conversely, those with nonlymphoblastic types (BT, NB, HI) treated with regimen 1 had a 58% RFS at 30 months compared to 32% for those treated on regimen 2 (P = 0.01). This study demonstrates that proper, routine histopathologic classification of NHL is the best criterion for choice of therapy in children with nonlocalized involvement. As a result of this study, all patients with nonlocalized disease, diagnosed after August 1980, were no longer randomized but were assigned to the appropriate treatment regimen based on prospective review of histopathology." @default.
• W2017059781 created "2016-06-24" @default.
• W2017059781 creator A5000471996 @default.
• W2017059781 creator A5005717601 @default.
• W2017059781 creator A5016730771 @default.
• W2017059781 creator A5017289724 @default.
• W2017059781 creator A5019094950 @default.
• W2017059781 creator A5028334828 @default.
• W2017059781 creator A5028949419 @default.
• W2017059781 creator A5033921210 @default.
• W2017059781 creator A5044402842 @default.
• W2017059781 creator A5047701227 @default.
• W2017059781 creator A5051208048 @default.
• W2017059781 creator A5066125248 @default.
• W2017059781 creator A5068326837 @default.
• W2017059781 creator A5074539240 @default.
• W2017059781 creator A5080942902 @default.
• W2017059781 date "1984-04-15" @default.
• W2017059781 modified "2023-09-27" @default.
• W2017059781 title "Studies on the pathology of non-Hodgkin's lymphoma of childhood: I. The role of routine histopathology as a prognostic factor a report from the childrens cancer study group" @default.
• W2017059781 cites W1965708817 @default.
• W2017059781 cites W1966804507 @default.
• W2017059781 cites W1990318898 @default.
• W2017059781 cites W1990575337 @default.
• W2017059781 cites W2005733321 @default.
• W2017059781 cites W2009816078 @default.
• W2017059781 cites W2033644503 @default.
• W2017059781 cites W2036404799 @default.
• W2017059781 cites W2037327334 @default.
• W2017059781 cites W2041915525 @default.
• W2017059781 cites W2057087596 @default.
• W2017059781 cites W2067232727 @default.
• W2017059781 cites W2069774450 @default.
• W2017059781 cites W2076426515 @default.
• W2017059781 cites W2078191540 @default.
• W2017059781 cites W2079538092 @default.
• W2017059781 cites W2082247228 @default.
• W2017059781 cites W2164684246 @default.
• W2017059781 cites W2316330924 @default.
• W2017059781 cites W2316542069 @default.
• W2017059781 cites W2325908000 @default.
• W2017059781 cites W2332960052 @default.
• W2017059781 cites W2335144896 @default.
• W2017059781 doi "https://doi.org/10.1002/1097-0142(19840415)53:8<1695::aid-cncr2820530813>3.0.co;2-u" @default.
• W2017059781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6697306" @default.
• W2017059781 hasPublicationYear "1984" @default.
• W2017059781 type Work @default.
• W2017059781 sameAs 2017059781 @default.
• W2017059781 citedByCount "54" @default.
• W2017059781 countsByYear W20170597812013 @default.
• W2017059781 crossrefType "journal-article" @default.
• W2017059781 hasAuthorship W2017059781A5000471996 @default.
• W2017059781 hasAuthorship W2017059781A5005717601 @default.
• W2017059781 hasAuthorship W2017059781A5016730771 @default.
• W2017059781 hasAuthorship W2017059781A5017289724 @default.
• W2017059781 hasAuthorship W2017059781A5019094950 @default.
• W2017059781 hasAuthorship W2017059781A5028334828 @default.
• W2017059781 hasAuthorship W2017059781A5028949419 @default.
• W2017059781 hasAuthorship W2017059781A5033921210 @default.
• W2017059781 hasAuthorship W2017059781A5044402842 @default.
• W2017059781 hasAuthorship W2017059781A5047701227 @default.
• W2017059781 hasAuthorship W2017059781A5051208048 @default.
• W2017059781 hasAuthorship W2017059781A5066125248 @default.
• W2017059781 hasAuthorship W2017059781A5068326837 @default.
• W2017059781 hasAuthorship W2017059781A5074539240 @default.
• W2017059781 hasAuthorship W2017059781A5080942902 @default.
• W2017059781 hasBestOaLocation W20170597811 @default.
• W2017059781 hasConcept C121608353 @default.
• W2017059781 hasConcept C126322002 @default.
• W2017059781 hasConcept C142724271 @default.
• W2017059781 hasConcept C143998085 @default.
• W2017059781 hasConcept C203014093 @default.
• W2017059781 hasConcept C2776090121 @default.
• W2017059781 hasConcept C2776694085 @default.
• W2017059781 hasConcept C2776755627 @default.
• W2017059781 hasConcept C2777478502 @default.
• W2017059781 hasConcept C2778720950 @default.
• W2017059781 hasConcept C2779338263 @default.
• W2017059781 hasConcept C2779429289 @default.
• W2017059781 hasConcept C2781413609 @default.
• W2017059781 hasConcept C544855455 @default.
• W2017059781 hasConcept C71924100 @default.
• W2017059781 hasConcept C8891405 @default.
• W2017059781 hasConcept C90924648 @default.
• W2017059781 hasConceptScore W2017059781C121608353 @default.
• W2017059781 hasConceptScore W2017059781C126322002 @default.
• W2017059781 hasConceptScore W2017059781C142724271 @default.
• W2017059781 hasConceptScore W2017059781C143998085 @default.
• W2017059781 hasConceptScore W2017059781C203014093 @default.
• W2017059781 hasConceptScore W2017059781C2776090121 @default.
• W2017059781 hasConceptScore W2017059781C2776694085 @default.
• W2017059781 hasConceptScore W2017059781C2776755627 @default.
• W2017059781 hasConceptScore W2017059781C2777478502 @default.
• W2017059781 hasConceptScore W2017059781C2778720950 @default.
• W2017059781 hasConceptScore W2017059781C2779338263 @default.
• W2017059781 hasConceptScore W2017059781C2779429289 @default.
• W2017059781 hasConceptScore W2017059781C2781413609 @default.
• W2017059781 hasConceptScore W2017059781C544855455 @default.

• next