Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017065764> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2017065764 endingPage "1250" @default.
- W2017065764 startingPage "1246" @default.
- W2017065764 abstract "In Brief We investigated the effects of isoflurane-induced burst suppression, monitored with electroencephalography (EEG), on cerebral blood flow velocity (CBFV), cerebral oxygen extraction (COE), and autoregulation in 16 patients undergoing cardiac surgery. The experimental procedure was performed during nonpulsatile cardiopulmonary bypass (CPB) with mild hypothermia (32°C) in fentanyl-anesthestized patients. Middle cerebral artery transcranial Doppler flow velocity, right jugular vein bulb oxygen saturation, and jugular venous pressure (JVP) were continuously measured. Autoregulation was tested during changes in mean arterial blood pressure (MAP) within a range of 40–80 mm Hg, induced by sodium nitroprusside and phenylephrine before (control) and during additional isoflurane administration to an EEG burst-suppression level of 6–9/min. Isoflurane induced a 27% decrease in CBFV (P < 0.05) and a 13% decrease in COE (P < 0.05) compared with control. The slope of the positive relationship between CBFV and cerebral perfusion pressure (CPP = MAP − JVP) was steeper with isoflurane (P < 0.05) compared with control, as was the slope of the negative relationship between CPP and COE (P < 0.05). We conclude that burst-suppression doses of isoflurane decrease CBFV and impair autoregulation of cerebral blood flow during mildly hypothermic CPB. Furthermore, during isoflurane administration, blood flow was in excess relative to oxygen demand, indicating a loss of metabolic autoregulation of flow. IMPLICATIONS: The effects of isoflurane on cerebral blood flow velocity (CBFV) and oxygen extraction (COE) as a function of perfusion pressure were studied. When added to fentanyl anesthesia, isoflurane induced a 27% and 13% decrease in CBFV and COE, respectively. CBFV became more pressure-dependent with isoflurane indicating an impaired autoregulation." @default.
- W2017065764 created "2016-06-24" @default.
- W2017065764 creator A5023745805 @default.
- W2017065764 creator A5027206436 @default.
- W2017065764 creator A5049822758 @default.
- W2017065764 creator A5052010639 @default.
- W2017065764 creator A5063740474 @default.
- W2017065764 creator A5088912289 @default.
- W2017065764 date "2003-11-01" @default.
- W2017065764 modified "2023-10-15" @default.
- W2017065764 title "The Effects of Isoflurane-Induced Electroencephalographic Burst Suppression on Cerebral Blood Flow Velocity and Cerebral Oxygen Extraction During Cardiopulmonary Bypass" @default.
- W2017065764 cites W1993578598 @default.
- W2017065764 cites W2019541577 @default.
- W2017065764 cites W2035590913 @default.
- W2017065764 cites W2040083618 @default.
- W2017065764 cites W2053165592 @default.
- W2017065764 cites W2054227747 @default.
- W2017065764 cites W2056464028 @default.
- W2017065764 cites W2067404499 @default.
- W2017065764 cites W2084781191 @default.
- W2017065764 cites W2095552123 @default.
- W2017065764 cites W2096365100 @default.
- W2017065764 cites W2111607494 @default.
- W2017065764 cites W2113964501 @default.
- W2017065764 cites W2116615254 @default.
- W2017065764 cites W2134366121 @default.
- W2017065764 cites W2140770928 @default.
- W2017065764 cites W2317954561 @default.
- W2017065764 cites W4299571371 @default.
- W2017065764 doi "https://doi.org/10.1213/01.ane.0000086732.97924.be" @default.
- W2017065764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14570630" @default.
- W2017065764 hasPublicationYear "2003" @default.
- W2017065764 type Work @default.
- W2017065764 sameAs 2017065764 @default.
- W2017065764 citedByCount "14" @default.
- W2017065764 countsByYear W20170657642012 @default.
- W2017065764 countsByYear W20170657642013 @default.
- W2017065764 countsByYear W20170657642014 @default.
- W2017065764 countsByYear W20170657642017 @default.
- W2017065764 countsByYear W20170657642019 @default.
- W2017065764 countsByYear W20170657642020 @default.
- W2017065764 countsByYear W20170657642021 @default.
- W2017065764 countsByYear W20170657642023 @default.
- W2017065764 crossrefType "journal-article" @default.
- W2017065764 hasAuthorship W2017065764A5023745805 @default.
- W2017065764 hasAuthorship W2017065764A5027206436 @default.
- W2017065764 hasAuthorship W2017065764A5049822758 @default.
- W2017065764 hasAuthorship W2017065764A5052010639 @default.
- W2017065764 hasAuthorship W2017065764A5063740474 @default.
- W2017065764 hasAuthorship W2017065764A5088912289 @default.
- W2017065764 hasBestOaLocation W20170657641 @default.
- W2017065764 hasConcept C111774379 @default.
- W2017065764 hasConcept C126322002 @default.
- W2017065764 hasConcept C154281038 @default.
- W2017065764 hasConcept C157767197 @default.
- W2017065764 hasConcept C164705383 @default.
- W2017065764 hasConcept C2775841333 @default.
- W2017065764 hasConcept C2776359302 @default.
- W2017065764 hasConcept C2778881276 @default.
- W2017065764 hasConcept C42219234 @default.
- W2017065764 hasConcept C541997718 @default.
- W2017065764 hasConcept C71924100 @default.
- W2017065764 hasConcept C84359808 @default.
- W2017065764 hasConcept C84393581 @default.
- W2017065764 hasConceptScore W2017065764C111774379 @default.
- W2017065764 hasConceptScore W2017065764C126322002 @default.
- W2017065764 hasConceptScore W2017065764C154281038 @default.
- W2017065764 hasConceptScore W2017065764C157767197 @default.
- W2017065764 hasConceptScore W2017065764C164705383 @default.
- W2017065764 hasConceptScore W2017065764C2775841333 @default.
- W2017065764 hasConceptScore W2017065764C2776359302 @default.
- W2017065764 hasConceptScore W2017065764C2778881276 @default.
- W2017065764 hasConceptScore W2017065764C42219234 @default.
- W2017065764 hasConceptScore W2017065764C541997718 @default.
- W2017065764 hasConceptScore W2017065764C71924100 @default.
- W2017065764 hasConceptScore W2017065764C84359808 @default.
- W2017065764 hasConceptScore W2017065764C84393581 @default.
- W2017065764 hasLocation W20170657641 @default.
- W2017065764 hasLocation W20170657642 @default.
- W2017065764 hasOpenAccess W2017065764 @default.
- W2017065764 hasPrimaryLocation W20170657641 @default.
- W2017065764 hasRelatedWork W1978082518 @default.
- W2017065764 hasRelatedWork W1983479534 @default.
- W2017065764 hasRelatedWork W2004607834 @default.
- W2017065764 hasRelatedWork W2318860532 @default.
- W2017065764 hasRelatedWork W2604389455 @default.
- W2017065764 hasRelatedWork W2771940247 @default.
- W2017065764 hasRelatedWork W2884519378 @default.
- W2017065764 hasRelatedWork W4288046334 @default.
- W2017065764 hasRelatedWork W4319825722 @default.
- W2017065764 hasRelatedWork W4376596107 @default.
- W2017065764 isParatext "false" @default.
- W2017065764 isRetracted "false" @default.
- W2017065764 magId "2017065764" @default.
- W2017065764 workType "article" @default.