Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017065778> ?p ?o ?g. }
- W2017065778 endingPage "78" @default.
- W2017065778 startingPage "72" @default.
- W2017065778 abstract "One-pot multicomponent synthesis to assemble compounds has been an efficient method for constructing a compound library. We have developed one-pot tandem copper-catalyzed azidation and CuAAC reactions that afford 1-thiazolyl-1,2,3-triazoles with anticancer activity. By utilizing this one-pot synthetic strategy, we constructed a library of 1-thiazolyl-1,2,3-triazoles in search of the potent lead compound. Furthermore, 1-thiazolyl-1,2,3-triazoles were evaluated for anticancer activity against the multidrug-resistant cancer cells MES-SA/Dx5. Most of the 1-thiazolyl-1,2,3-triazoles revealed cytotoxic effect against cancer cells at micromolar to low micromolar range. Testing some of the most potent compounds (5{4,2-4} and 5{5,1-3}) against the normal cell line Vero showed no significant toxicity (except 5{4,2}) to normal cells. This result indicates that compounds 5{4,3-4} and 5{5,1-3} possessed good potency and selectivity to cancer cells over normal cells." @default.
- W2017065778 created "2016-06-24" @default.
- W2017065778 creator A5006026846 @default.
- W2017065778 creator A5034032872 @default.
- W2017065778 creator A5043850151 @default.
- W2017065778 creator A5064314691 @default.
- W2017065778 creator A5075344136 @default.
- W2017065778 date "2010-11-10" @default.
- W2017065778 modified "2023-09-24" @default.
- W2017065778 title "One-Pot Tandem Copper-Catalyzed Library Synthesis of 1-Thiazolyl-1,2,3-triazoles as Anticancer Agents" @default.
- W2017065778 cites W1966069936 @default.
- W2017065778 cites W1969020431 @default.
- W2017065778 cites W1978455823 @default.
- W2017065778 cites W1984180549 @default.
- W2017065778 cites W1999906396 @default.
- W2017065778 cites W2003627722 @default.
- W2017065778 cites W2004167475 @default.
- W2017065778 cites W2011058141 @default.
- W2017065778 cites W2011218110 @default.
- W2017065778 cites W2017662055 @default.
- W2017065778 cites W2021078959 @default.
- W2017065778 cites W2023557482 @default.
- W2017065778 cites W2026163749 @default.
- W2017065778 cites W2030361672 @default.
- W2017065778 cites W2034276638 @default.
- W2017065778 cites W2035409502 @default.
- W2017065778 cites W2037335536 @default.
- W2017065778 cites W2039443548 @default.
- W2017065778 cites W2049257274 @default.
- W2017065778 cites W2057118933 @default.
- W2017065778 cites W2065777323 @default.
- W2017065778 cites W2066128768 @default.
- W2017065778 cites W2069943237 @default.
- W2017065778 cites W2113411356 @default.
- W2017065778 cites W2952508346 @default.
- W2017065778 cites W2952864655 @default.
- W2017065778 cites W2953078591 @default.
- W2017065778 cites W4254774664 @default.
- W2017065778 cites W2003457394 @default.
- W2017065778 doi "https://doi.org/10.1021/co1000234" @default.
- W2017065778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21247128" @default.
- W2017065778 hasPublicationYear "2010" @default.
- W2017065778 type Work @default.
- W2017065778 sameAs 2017065778 @default.
- W2017065778 citedByCount "50" @default.
- W2017065778 countsByYear W20170657782012 @default.
- W2017065778 countsByYear W20170657782013 @default.
- W2017065778 countsByYear W20170657782014 @default.
- W2017065778 countsByYear W20170657782015 @default.
- W2017065778 countsByYear W20170657782016 @default.
- W2017065778 countsByYear W20170657782017 @default.
- W2017065778 countsByYear W20170657782018 @default.
- W2017065778 countsByYear W20170657782019 @default.
- W2017065778 countsByYear W20170657782020 @default.
- W2017065778 countsByYear W20170657782021 @default.
- W2017065778 countsByYear W20170657782022 @default.
- W2017065778 countsByYear W20170657782023 @default.
- W2017065778 crossrefType "journal-article" @default.
- W2017065778 hasAuthorship W2017065778A5006026846 @default.
- W2017065778 hasAuthorship W2017065778A5034032872 @default.
- W2017065778 hasAuthorship W2017065778A5043850151 @default.
- W2017065778 hasAuthorship W2017065778A5064314691 @default.
- W2017065778 hasAuthorship W2017065778A5075344136 @default.
- W2017065778 hasBestOaLocation W20170657782 @default.
- W2017065778 hasConcept C121608353 @default.
- W2017065778 hasConcept C126322002 @default.
- W2017065778 hasConcept C159985019 @default.
- W2017065778 hasConcept C161790260 @default.
- W2017065778 hasConcept C178790620 @default.
- W2017065778 hasConcept C185592680 @default.
- W2017065778 hasConcept C192562407 @default.
- W2017065778 hasConcept C202751555 @default.
- W2017065778 hasConcept C21951064 @default.
- W2017065778 hasConcept C2777814067 @default.
- W2017065778 hasConcept C2994372470 @default.
- W2017065778 hasConcept C544778455 @default.
- W2017065778 hasConcept C55493867 @default.
- W2017065778 hasConcept C57992300 @default.
- W2017065778 hasConcept C71240020 @default.
- W2017065778 hasConcept C71924100 @default.
- W2017065778 hasConcept C89138240 @default.
- W2017065778 hasConcept C96232424 @default.
- W2017065778 hasConceptScore W2017065778C121608353 @default.
- W2017065778 hasConceptScore W2017065778C126322002 @default.
- W2017065778 hasConceptScore W2017065778C159985019 @default.
- W2017065778 hasConceptScore W2017065778C161790260 @default.
- W2017065778 hasConceptScore W2017065778C178790620 @default.
- W2017065778 hasConceptScore W2017065778C185592680 @default.
- W2017065778 hasConceptScore W2017065778C192562407 @default.
- W2017065778 hasConceptScore W2017065778C202751555 @default.
- W2017065778 hasConceptScore W2017065778C21951064 @default.
- W2017065778 hasConceptScore W2017065778C2777814067 @default.
- W2017065778 hasConceptScore W2017065778C2994372470 @default.
- W2017065778 hasConceptScore W2017065778C544778455 @default.
- W2017065778 hasConceptScore W2017065778C55493867 @default.
- W2017065778 hasConceptScore W2017065778C57992300 @default.
- W2017065778 hasConceptScore W2017065778C71240020 @default.
- W2017065778 hasConceptScore W2017065778C71924100 @default.