FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017071095> ?p ?o ?g. }

• W2017071095 endingPage "274" @default.
• W2017071095 startingPage "267" @default.
• W2017071095 abstract "According to international guidelines, nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are the cornerstone drugs for cancer pain. In clinical practice, severe cancer pain often requires 3 step analgesics and alternative routes of administration, thus NSAIDs are usually abandoned. Our aim was to evaluate feasibility, safety, and efficacy of ketoprofen combined with opioids in long-term continuous subcutaneous infusion (CSI) for cancer pain in a prospective observational open-label pilot study.Ketoprofen was added to morphine CSI in 172 consecutive patients (study group, SG). Concomitantly, 48 received opioids CSI without ketoprofen for contraindication to NSAIDs (control group, CG). CSI was delivered through a single-use elastomeric pump refilled weekly. Safety was evaluated according to the number of adverse events and their severity. The measures of efficacy were pain relief (NRS, Numerical Rating Scale), percentage of patients that needed to increase morphine dosage, and median relative increase between weeks 2 and 4.Toxicity typically attributable to NSAIDs were recorded in 4.1% of patients after 3 months of treatment and the combination of NSAIDs and corticosteroids seems not to influence the risk of gastrointestinal adverse effects. The local side effects related to the CSI regimen were negligible in both the groups. By the fourth week, pain was well controlled (NRS 0 to 2) in 80% of patients receiving ketoprofen compared with 46% of patients without ketoprofen (P<0.01.) Moreover, the percentage of patients needing to increase the morphine dosage (40.5% vs. 68.7% P<0.01) and the relative dose increase (12% vs. 25% P<0.005) were significantly lower in the SG.Ketoprofen CSI in combination with opioids is a feasible, safe, and effective approach to cancer pain." @default.
• W2017071095 created "2016-06-24" @default.
• W2017071095 creator A5004936748 @default.
• W2017071095 creator A5006128795 @default.
• W2017071095 creator A5018901602 @default.
• W2017071095 creator A5019233117 @default.
• W2017071095 creator A5067713530 @default.
• W2017071095 date "2010-05-01" @default.
• W2017071095 modified "2023-10-18" @default.
• W2017071095 title "Long-term Continuous Subcutaneous Infusion of Ketoprofen Combined With Morphine: A Safe and Effective Approach to Cancer Pain" @default.
• W2017071095 cites W1919669891 @default.
• W2017071095 cites W1947513009 @default.
• W2017071095 cites W1972916392 @default.
• W2017071095 cites W2002444590 @default.
• W2017071095 cites W2038688257 @default.
• W2017071095 cites W2038895209 @default.
• W2017071095 cites W2043026135 @default.
• W2017071095 cites W2058216206 @default.
• W2017071095 cites W2061892234 @default.
• W2017071095 cites W2068838925 @default.
• W2017071095 cites W2069068496 @default.
• W2017071095 cites W2076974583 @default.
• W2017071095 cites W2078294506 @default.
• W2017071095 cites W2078388299 @default.
• W2017071095 cites W2080745496 @default.
• W2017071095 cites W2094079527 @default.
• W2017071095 cites W2111030150 @default.
• W2017071095 cites W2126356457 @default.
• W2017071095 cites W2590894951 @default.
• W2017071095 cites W37371421 @default.
• W2017071095 doi "https://doi.org/10.1097/ajp.0b013e3181c20221" @default.
• W2017071095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20393260" @default.
• W2017071095 hasPublicationYear "2010" @default.
• W2017071095 type Work @default.
• W2017071095 sameAs 2017071095 @default.
• W2017071095 citedByCount "11" @default.
• W2017071095 countsByYear W20170710952012 @default.
• W2017071095 countsByYear W20170710952013 @default.
• W2017071095 countsByYear W20170710952014 @default.
• W2017071095 countsByYear W20170710952015 @default.
• W2017071095 countsByYear W20170710952021 @default.
• W2017071095 crossrefType "journal-article" @default.
• W2017071095 hasAuthorship W2017071095A5004936748 @default.
• W2017071095 hasAuthorship W2017071095A5006128795 @default.
• W2017071095 hasAuthorship W2017071095A5018901602 @default.
• W2017071095 hasAuthorship W2017071095A5019233117 @default.
• W2017071095 hasAuthorship W2017071095A5067713530 @default.
• W2017071095 hasConcept C121608353 @default.
• W2017071095 hasConcept C126322002 @default.
• W2017071095 hasConcept C141071460 @default.
• W2017071095 hasConcept C142724271 @default.
• W2017071095 hasConcept C170493617 @default.
• W2017071095 hasConcept C197934379 @default.
• W2017071095 hasConcept C204787440 @default.
• W2017071095 hasConcept C2776494729 @default.
• W2017071095 hasConcept C2777389121 @default.
• W2017071095 hasConcept C2778904085 @default.
• W2017071095 hasConcept C2780744026 @default.
• W2017071095 hasConcept C2780820201 @default.
• W2017071095 hasConcept C2781063702 @default.
• W2017071095 hasConcept C2781413609 @default.
• W2017071095 hasConcept C42219234 @default.
• W2017071095 hasConcept C71924100 @default.
• W2017071095 hasConcept C98274493 @default.
• W2017071095 hasConceptScore W2017071095C121608353 @default.
• W2017071095 hasConceptScore W2017071095C126322002 @default.
• W2017071095 hasConceptScore W2017071095C141071460 @default.
• W2017071095 hasConceptScore W2017071095C142724271 @default.
• W2017071095 hasConceptScore W2017071095C170493617 @default.
• W2017071095 hasConceptScore W2017071095C197934379 @default.
• W2017071095 hasConceptScore W2017071095C204787440 @default.
• W2017071095 hasConceptScore W2017071095C2776494729 @default.
• W2017071095 hasConceptScore W2017071095C2777389121 @default.
• W2017071095 hasConceptScore W2017071095C2778904085 @default.
• W2017071095 hasConceptScore W2017071095C2780744026 @default.
• W2017071095 hasConceptScore W2017071095C2780820201 @default.
• W2017071095 hasConceptScore W2017071095C2781063702 @default.
• W2017071095 hasConceptScore W2017071095C2781413609 @default.
• W2017071095 hasConceptScore W2017071095C42219234 @default.
• W2017071095 hasConceptScore W2017071095C71924100 @default.
• W2017071095 hasConceptScore W2017071095C98274493 @default.
• W2017071095 hasIssue "4" @default.
• W2017071095 hasLocation W20170710951 @default.
• W2017071095 hasLocation W20170710952 @default.
• W2017071095 hasOpenAccess W2017071095 @default.
• W2017071095 hasPrimaryLocation W20170710951 @default.
• W2017071095 hasRelatedWork W1837738291 @default.
• W2017071095 hasRelatedWork W1976954588 @default.
• W2017071095 hasRelatedWork W2038895209 @default.
• W2017071095 hasRelatedWork W2057643659 @default.
• W2017071095 hasRelatedWork W2084209973 @default.
• W2017071095 hasRelatedWork W2138094753 @default.
• W2017071095 hasRelatedWork W2371241698 @default.
• W2017071095 hasRelatedWork W2488311222 @default.
• W2017071095 hasRelatedWork W4246921426 @default.
• W2017071095 hasRelatedWork W2485872855 @default.
• W2017071095 hasVolume "26" @default.
• W2017071095 isParatext "false" @default.

• next