Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017071821> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2017071821 abstract "The development of atherosclerotic cardiovascular complications is a common and serious problem for the long-term survivors of organ transplantation. Cyclosporine A plus steroid-based immuno-suppression regimens in these patients are associated with the development of hypertension, hyperlipidemia, obesity, and diabetes mellitus. Whether the new immunosuppressive agent tacrolimus (FK506) confers any advantage in terms of these cardiovascular risk factors has been less well studied. We compared serial changes in blood pressure, lipids, body weight, and glucose levels during the first 12 months after liver transplantation in patients using either cyclosporine A (n = 39) or tacrolimus (n = 24)-based immunosuppression. By 12 months, the prevalence of hypertension, hypercholesterolemia, and obesity was increased in the cyclosporine A group compared to tacrolimus: 82% versus 33%, 33% versus 0%, and 46% versus 29%, respectively (all p < .05). Triglyceride and total cholesterol levels were 196 +/- 23 versus 125 +/- 13 mg/dL and 225 +/- 9 versus 159 +/- 7 mg/dL for the cyclosporine A versus tacrolimus groups, respectively (p < .05). Cumulative posttransplant steroid dose was not related to the observed lipid changes in either group, although the increase in triglycerides was positively correlated to weight gain and diuretic use in the cyclosporine A group. The incidence of diabetes mellitus was not increased from baseline in either group. These results indicate that tacrolimus, compared to cyclosporine A, is associated with a less adverse cardiovascular risk profile in the first year after liver transplantation. Whether these differences persist and become clinically relevant to a liver transplant recipient population that is increasingly older and has more preexisting cardiovascular disease remains to be determined." @default.
- W2017071821 created "2016-06-24" @default.
- W2017071821 creator A5012905645 @default.
- W2017071821 creator A5054189110 @default.
- W2017071821 creator A5058722354 @default.
- W2017071821 creator A5061717823 @default.
- W2017071821 creator A5066274313 @default.
- W2017071821 creator A5079447750 @default.
- W2017071821 creator A5084687592 @default.
- W2017071821 date "1997-06-01" @default.
- W2017071821 modified "2023-09-26" @default.
- W2017071821 title "Evolution of cardiovascular risk after liver transplantation: A comparison of cyclosporine A and tacrolimus (FK506)" @default.
- W2017071821 doi "https://doi.org/10.1016/s0928-4346(97)85792-1" @default.
- W2017071821 hasPublicationYear "1997" @default.
- W2017071821 type Work @default.
- W2017071821 sameAs 2017071821 @default.
- W2017071821 citedByCount "0" @default.
- W2017071821 crossrefType "journal-article" @default.
- W2017071821 hasAuthorship W2017071821A5012905645 @default.
- W2017071821 hasAuthorship W2017071821A5054189110 @default.
- W2017071821 hasAuthorship W2017071821A5058722354 @default.
- W2017071821 hasAuthorship W2017071821A5061717823 @default.
- W2017071821 hasAuthorship W2017071821A5066274313 @default.
- W2017071821 hasAuthorship W2017071821A5079447750 @default.
- W2017071821 hasAuthorship W2017071821A5084687592 @default.
- W2017071821 hasConcept C126322002 @default.
- W2017071821 hasConcept C134018914 @default.
- W2017071821 hasConcept C197934379 @default.
- W2017071821 hasConcept C2779091943 @default.
- W2017071821 hasConcept C2779609443 @default.
- W2017071821 hasConcept C2780252810 @default.
- W2017071821 hasConcept C2908647359 @default.
- W2017071821 hasConcept C2909675724 @default.
- W2017071821 hasConcept C2911091166 @default.
- W2017071821 hasConcept C555293320 @default.
- W2017071821 hasConcept C71924100 @default.
- W2017071821 hasConcept C88879693 @default.
- W2017071821 hasConcept C90924648 @default.
- W2017071821 hasConcept C99454951 @default.
- W2017071821 hasConceptScore W2017071821C126322002 @default.
- W2017071821 hasConceptScore W2017071821C134018914 @default.
- W2017071821 hasConceptScore W2017071821C197934379 @default.
- W2017071821 hasConceptScore W2017071821C2779091943 @default.
- W2017071821 hasConceptScore W2017071821C2779609443 @default.
- W2017071821 hasConceptScore W2017071821C2780252810 @default.
- W2017071821 hasConceptScore W2017071821C2908647359 @default.
- W2017071821 hasConceptScore W2017071821C2909675724 @default.
- W2017071821 hasConceptScore W2017071821C2911091166 @default.
- W2017071821 hasConceptScore W2017071821C555293320 @default.
- W2017071821 hasConceptScore W2017071821C71924100 @default.
- W2017071821 hasConceptScore W2017071821C88879693 @default.
- W2017071821 hasConceptScore W2017071821C90924648 @default.
- W2017071821 hasConceptScore W2017071821C99454951 @default.
- W2017071821 hasLocation W20170718211 @default.
- W2017071821 hasOpenAccess W2017071821 @default.
- W2017071821 hasPrimaryLocation W20170718211 @default.
- W2017071821 hasRelatedWork W1480998774 @default.
- W2017071821 hasRelatedWork W1907636864 @default.
- W2017071821 hasRelatedWork W1967020106 @default.
- W2017071821 hasRelatedWork W1983557637 @default.
- W2017071821 hasRelatedWork W1985012243 @default.
- W2017071821 hasRelatedWork W2011989170 @default.
- W2017071821 hasRelatedWork W2014186004 @default.
- W2017071821 hasRelatedWork W2021426718 @default.
- W2017071821 hasRelatedWork W2023573350 @default.
- W2017071821 hasRelatedWork W2057494890 @default.
- W2017071821 hasRelatedWork W2060789833 @default.
- W2017071821 hasRelatedWork W2082615590 @default.
- W2017071821 hasRelatedWork W2090959382 @default.
- W2017071821 hasRelatedWork W2104697087 @default.
- W2017071821 hasRelatedWork W2159986277 @default.
- W2017071821 hasRelatedWork W2349382019 @default.
- W2017071821 hasRelatedWork W2368897260 @default.
- W2017071821 hasRelatedWork W2387255220 @default.
- W2017071821 hasRelatedWork W2994271832 @default.
- W2017071821 hasRelatedWork W2341154876 @default.
- W2017071821 isParatext "false" @default.
- W2017071821 isRetracted "false" @default.
- W2017071821 magId "2017071821" @default.
- W2017071821 workType "article" @default.