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- W2017075360 abstract "The aim of our study was to characterize the receptor binding of human α-atrial natriuretic peptide (ANP) to easily available human cells. Blood cells possess receptors for peptide hormones as for instance platelets for vasopressin. We therefore, investigated the presence of receptors for ANP on human peripheral blood cells from adult volunteers. Whereas no receptors were detected on red cells, mononuclear cells and granulocytes, we found ANP-receptors on human platelets. The binding studies were performed by incubating 40 × 106 platelets with 125J-ANP(103-106 cpm) and the competing ligand, when used, in a total incubation volume of 1 ml. Centrifugation was used to separate bound from free hormone. Specific binding of 125J-ANP was rapid, saturable and reversible. A steady state was achieved whithin 90 minutes. Scatchard analysis of saturation and competition experiments demonstrated the existence of one class of high affinity binding sites for ANP with a Kd of 8-16 pM and 10-26 receptors per cell. The Kd obtained in our binding studies was in the range of physiological ANP concentrations in human plasma (8-20 pM). Although characterization of platelet ANP receptors has the inherent disadvantage that they are few, they could be a useful model to investigate ANP receptor-status under different physiological and pathological conditions in man." @default.
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- W2017075360 date "1986-11-01" @default.
- W2017075360 modified "2023-10-16" @default.
- W2017075360 title "CHARACTERIZATION OF SPEZIFIC RECEPTORS FOR ATRIAL NATRIURETIC PEPTIDE ON HUMAN PLATELETS" @default.
- W2017075360 doi "https://doi.org/10.1203/00006450-198611000-00181" @default.
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