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- W2017075892 abstract "Human immunodeficiency virus tyoe 1 (HIV-1) Vif counteracts host restriction cytidine deaminase (APOBEC3G) A3G by co-opting the cellular ubiquitin-proteasome machinery. Vif utilizes a viral-specific BC-box to recruit ElonginB-ElonginC and a novel zinc-binding HCCH motif to recruit Cullin5 (Cul5) to form an E3 ubiquitin ligase targeting A3G for polyubiquitination and subsequently proteasomal degradation. To determine the structural requirements in HIV-1 Vif HCCH motif for Cul5 binding and Vif function, we investigated the arrangement of the His and Cys residues, the role of the spacing between them, and the requirement for the conserved residues. Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5. Moreover, the maintenance of both conserved residues and spacing within the HCCH motif is critical for Vif function. We have identified a ”viral Cul5 box” with consensus Hx2YFxCFx4Φx2AΦx7-8Cx5H that is required for Cul5 selection and subsequent A3G degradation. This novel motif may represent a potential new target for anti-viral drug development." @default.
- W2017075892 created "2016-06-24" @default.
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- W2017075892 date "2007-10-01" @default.
- W2017075892 modified "2023-09-23" @default.
- W2017075892 title "Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif" @default.
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- W2017075892 cites W1966343819 @default.
- W2017075892 cites W1966477735 @default.
- W2017075892 cites W1967513429 @default.
- W2017075892 cites W1971758177 @default.
- W2017075892 cites W1973598278 @default.
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- W2017075892 cites W2000620255 @default.
- W2017075892 cites W2004640739 @default.
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- W2017075892 cites W2007978409 @default.
- W2017075892 cites W2009808421 @default.
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- W2017075892 cites W2015820342 @default.
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- W2017075892 cites W2035939622 @default.
- W2017075892 cites W2039773345 @default.
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- W2017075892 doi "https://doi.org/10.1016/j.jmb.2007.07.029" @default.
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