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- W2017077293 abstract "Endoscopy is arguably the golden standard for the initial diagnosis of Crohn’s disease (CD), but the role of endoscopic mucosal healing in the assessment of treatment response or in predicting the course of the disease is more controversial. Endoscopic indices of severity have been developed but have failed to correlate with response to standard treatments such as corticosteroids and aminosalicylates. Immunosuppressives induce mucosal healing with an interval of months. The anti-TNF monoclonal antibody infliximab, leads to rapid and complete disappearance of mucosal ulcers. Clinical improvement with infliximab also correlates with improvement in the endoscopic severity index. Systematic 8 weekly maintenance treatment with infliximab induces mucosal healing as long as the therapy is continued. However, clinical trial and practice experience indicate that the healing of the mucosa does not persist when infliximab is interrupted. The dramatic effect of infliximab on endoscopic mucosal healing has reset the standards for future drug development, but several questions remain unanswered. It is still unclear whether endoscopic healing predicts a long-term favorable outcome. Also data demonstrating that endoscopic healing prevents complications are limited and should be confirmed. However, at this moment the body of evidence supporting the use of mucosal healing as an objective biological parameter of short-term efficacy in CD is sufficient to consider endoscopy as an essential component of clinical trial outcomes." @default.
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- W2017077293 date "2004-10-01" @default.
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- W2017077293 title "The role and importance of endoscopic mucosal healing in Crohn’s disease" @default.
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- W2017077293 doi "https://doi.org/10.1016/j.tgie.2004.09.001" @default.
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