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- W2017079460 abstract "There has been recent evidence that Gz may play a role in the transmission of the neurotrophic signal from nerve terminals to the cell bodies [Johanson, S.O., Crouch, M.F., Hendry, I.A., Signal transduction from membrane to nucleus: the special case for neurons, Neurochem. Res. 21 (1996) 779–785]. We examined the developmental expression of the α subunit of Gz (Gzα) in the peripheral and central nervous systems of the mouse. Our laboratory has developed a quantitative reverse transcription-polymerase chain reaction (RT-PCR) for Gzα which makes use of a fragment of the PCR product shortened by 107 base pairs creating a standard which mimics the original RNA. Serial dilutions of the mouse RNA with a constant concentration of mimic RNA were made and the point where equal amounts of product are formed allows accurate measurement of Gzα mRNA in the tissue. We have demonstrated that in the developing mouse superior cervical ganglion (SCG), dorsal root ganglion (DRG) and trigeminal ganglion the expression of Gzα mRNA is highest perinatally. From 3 weeks of age, in all tissues with the exception of the SCG, Gzα mRNA levels fall to lower levels in the adult animal. The developmental pattern of expression of Gzα in both the cerebellum and the brain differs from the peripheral nervous system. In the cerebellum, Gzα mRNA expression is highest around birth and in the brain it is highest around third postnatal week and then the levels decline as adulthood is approached. These results suggest that the highest level of Gzα mRNA is expressed at the time when target tissue innervation is occurring. This further strengthens the hypothesis that Gzα is important in the transfer of information from target tissues to the innervating nerve cells." @default.
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- W2017079460 date "1998-05-01" @default.
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- W2017079460 title "Developmental expression of messenger RNA levels of the α subunit of the GTP-binding protein, Gz, in the mouse nervous system" @default.
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- W2017079460 doi "https://doi.org/10.1016/s0165-3806(98)00020-0" @default.
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