FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017079862> ?p ?o ?g. }

• W2017079862 endingPage "522" @default.
• W2017079862 startingPage "513" @default.
• W2017079862 abstract "p16, a surrogate marker for human papillomavirus (HPV) infection, is uniformly present in HPV-related carcinomas. This study aims to further characterize p16 expression in trophoblastic lesions and squamous lesions of the upper female genital tract, as little data exists. p16 immunostaining was performed on sections from ichthyosis uteri (1), primary uterine corpus squamous cell carcinoma (UCSCC) (2), primary ovarian SCC (OSCC) (5; 2 associated with a dermoid cyst), endometrial endometrioid adenocarcinoma with extensive squamous differentiation (EC-SD) (5), ovarian endometrioid adenocarcinoma with extensive squamous differentiation (OC-SD) (4), placental site nodule (5), and placental site trophoblastic tumor (PSTT) (6). We evaluated the percentage of positive cytoplasmic and nuclear staining (focal=<10%, multifocal=10% to 50%, and diffuse=>50%) and staining intensity (weak, moderate, and strong). HPV-DNA analysis by polymerase chain reaction was performed on 5 OSCC. Ichthyosis uteri, all UCSCC and 1 OSCC (arising in a dermoid) were negative; the other dermoid-associated OSCC showed focal moderate staining, the remaining OSCC displayed strong (100%), diffuse (2), or multifocal (1) p16 positivity. Three of the 5 EC-SD cases showed strong diffuse staining of the squamous component. The glandular component focally showed strong p16 positivity (2), with variably intense focal staining in 3 cases. The squamous component of all OC-SD showed focal moderate staining, with variable staining of the glandular component. Overall, 3 EC-SD had 80% to 90% p16 positivity. Five of the 5 placental site nodules and 4 of the 6 PSTT showed focal weak staining, whereas 2 PSTT were p16 negative. HPV-DNA analysis was negative in 3 of the 5 OSCC, the other 2 cases being technical failures. p16 is expressed in OSCC and in the squamous and glandular components of EC-SD and OC-SD. As p16 is negative in UCSCC, it may help to identify the origin of SCC diffusely involving the corpus and cervix, and suggests different pathogeneses for SCC of the upper female genital tract, likely to be unrelated to HPV infection. In contrast to earlier data, we found weak and focal p16 expression in trophoblastic lesions. Thus, when considering the differential diagnosis of cervical SCC and trophoblastic lesions, only strong diffuse p16 staining should be considered helpful." @default.
• W2017079862 created "2016-06-24" @default.
• W2017079862 creator A5034015760 @default.
• W2017079862 creator A5035109058 @default.
• W2017079862 creator A5044336442 @default.
• W2017079862 creator A5052359409 @default.
• W2017079862 creator A5053542215 @default.
• W2017079862 creator A5056961342 @default.
• W2017079862 creator A5080737144 @default.
• W2017079862 date "2010-11-01" @default.
• W2017079862 modified "2023-10-16" @default.
• W2017079862 title "p16 Expression in Squamous and Trophoblastic Lesions of the Upper Female Genital Tract" @default.
• W2017079862 cites W1498755601 @default.
• W2017079862 cites W1632650447 @default.
• W2017079862 cites W1964137925 @default.
• W2017079862 cites W1966791428 @default.
• W2017079862 cites W1972116577 @default.
• W2017079862 cites W1973358395 @default.
• W2017079862 cites W1977396046 @default.
• W2017079862 cites W1983659393 @default.
• W2017079862 cites W1984463181 @default.
• W2017079862 cites W1991368774 @default.
• W2017079862 cites W1993714073 @default.
• W2017079862 cites W1994643035 @default.
• W2017079862 cites W1994962761 @default.
• W2017079862 cites W1998218812 @default.
• W2017079862 cites W1998349535 @default.
• W2017079862 cites W1999330214 @default.
• W2017079862 cites W2006462902 @default.
• W2017079862 cites W2006901271 @default.
• W2017079862 cites W2009676159 @default.
• W2017079862 cites W2013801177 @default.
• W2017079862 cites W2014459552 @default.
• W2017079862 cites W2015119039 @default.
• W2017079862 cites W2018086697 @default.
• W2017079862 cites W2020461527 @default.
• W2017079862 cites W2022358833 @default.
• W2017079862 cites W2023271527 @default.
• W2017079862 cites W2025604216 @default.
• W2017079862 cites W2027093025 @default.
• W2017079862 cites W2030027267 @default.
• W2017079862 cites W2032953029 @default.
• W2017079862 cites W2035849601 @default.
• W2017079862 cites W2036160672 @default.
• W2017079862 cites W2037102662 @default.
• W2017079862 cites W2042403711 @default.
• W2017079862 cites W2043046853 @default.
• W2017079862 cites W2043099617 @default.
• W2017079862 cites W2045635675 @default.
• W2017079862 cites W2046238584 @default.
• W2017079862 cites W2051692395 @default.
• W2017079862 cites W2053889509 @default.
• W2017079862 cites W2055553397 @default.
• W2017079862 cites W2060241442 @default.
• W2017079862 cites W2064186080 @default.
• W2017079862 cites W2065027700 @default.
• W2017079862 cites W2065535575 @default.
• W2017079862 cites W2066848701 @default.
• W2017079862 cites W2067457037 @default.
• W2017079862 cites W2067544966 @default.
• W2017079862 cites W2067791554 @default.
• W2017079862 cites W2068372669 @default.
• W2017079862 cites W2070300951 @default.
• W2017079862 cites W2075821908 @default.
• W2017079862 cites W2078117633 @default.
• W2017079862 cites W2083631295 @default.
• W2017079862 cites W2084506676 @default.
• W2017079862 cites W2085447799 @default.
• W2017079862 cites W2085806332 @default.
• W2017079862 cites W2086687368 @default.
• W2017079862 cites W2093414202 @default.
• W2017079862 cites W2098475608 @default.
• W2017079862 cites W2102282815 @default.
• W2017079862 cites W2315736303 @default.
• W2017079862 cites W2326118456 @default.
• W2017079862 cites W33820357 @default.
• W2017079862 cites W4253388594 @default.
• W2017079862 doi "https://doi.org/10.1097/pgp.0b013e3181e2fe70" @default.
• W2017079862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20881863" @default.
• W2017079862 hasPublicationYear "2010" @default.
• W2017079862 type Work @default.
• W2017079862 sameAs 2017079862 @default.
• W2017079862 citedByCount "18" @default.
• W2017079862 countsByYear W20170798622012 @default.
• W2017079862 countsByYear W20170798622014 @default.
• W2017079862 countsByYear W20170798622015 @default.
• W2017079862 countsByYear W20170798622016 @default.
• W2017079862 countsByYear W20170798622019 @default.
• W2017079862 countsByYear W20170798622020 @default.
• W2017079862 countsByYear W20170798622021 @default.
• W2017079862 countsByYear W20170798622022 @default.
• W2017079862 countsByYear W20170798622023 @default.
• W2017079862 crossrefType "journal-article" @default.
• W2017079862 hasAuthorship W2017079862A5034015760 @default.
• W2017079862 hasAuthorship W2017079862A5035109058 @default.
• W2017079862 hasAuthorship W2017079862A5044336442 @default.
• W2017079862 hasAuthorship W2017079862A5052359409 @default.
• W2017079862 hasAuthorship W2017079862A5053542215 @default.

• next