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- W2017084178 abstract "We investigate the dynamic response of single cells to weak and local rigidities, applied at controlled adhesion sites. Using multiple latex beads functionalized with fibronectin, and each trapped in its own optical trap, we study the reaction in real time of single 3T3 fibroblast cells to asymmetrical tensions in the tens of pN ·μm−1 range. We show that the cell feels a rigidity gradient even at this low range of tension, and over time develops an adapted change in the force exerted on each adhesion site. The rate at which force increases is proportional to trap stiffness. Actomyosin recruitment is regulated in space and time along the rigidity gradient, resulting in a linear relationship between the amount of recruited actin and the force developed independently in trap stiffness. This time-regulated actomyosin behavior sustains a constant and rigidity-independent velocity of beads inside the traps. Our results show that the strengthening of extracellular matrix-cytoskeleton linkages along a rigidity gradient is regulated by controlling adhesion area and actomyosin recruitment, to maintain a constant deformation of the extracellular matrix." @default.
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- W2017084178 date "2009-01-01" @default.
- W2017084178 modified "2023-10-17" @default.
- W2017084178 title "Spatiotemporal Analysis of Cell Response to a Rigidity Gradient: A Quantitative Study Using Multiple Optical Tweezers" @default.
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- W2017084178 doi "https://doi.org/10.1529/biophysj.108.134627" @default.
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