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• W2017085953 abstract "Although CD8 T cells are thought to be a principal effector population of graft-versus-host disease (GVHD), their dynamics and specificity remain a mystery. Using a mouse model in which donor and recipient were incompatible at many minor histocompatibility antigens (minor H Ags), the CD8 T-cell response was tracked temporally and spatially through the course of GVHD. Donor CD8 T cells in the circulation, spleen, lung, and liver demonstrated virtually identical kinetics: rapid expansion and then decline prior to morbidity. Remarkably, up to one fourth of the CD8 T cells were directed against a single minor antigen, H60. Extreme H60 immunodominance occurred regardless of sampling time, site, and genetic background. This study is the first to analyze the T cells participating in GVHD in “real-time,” demonstrates the exceptional degree to which immunodominance of H60 can occur, and suggests that such superdominant minor H Ags could be risk factors for GVHD." @default.
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• W2017085953 date "2002-12-15" @default.
• W2017085953 modified "2023-10-16" @default.
• W2017085953 title "Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease" @default.
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• W2017085953 doi "https://doi.org/10.1182/blood-2002-05-1299" @default.
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