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- W2017088082 abstract "<h3>Abstract</h3> Long intergenic non-coding RNAs (lincRNAs) have been implicated in aspects of gene regulation, but their requirement for development needs empirical interrogation. To begin to understand the roles lincRNAs might play in heart development, we computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had in vivo expression patterns supporting a potential function in heart development, including a transcript downstream of the cardiac transcription factor <i>Hand2</i> that we named <i>Handlr (Hand2</i>-associated lincRNA), <i>Rubie,</i> and <i>Atcayos</i>. We genetically ablated these six lincRNAs in mouse, which implicated genomic regulatory roles to four of the cohort, However, none of the lincRNA deletions led to severe cardiac phenotypes. Thus, we stressed the hearts of adult <i>Handlr</i> and <i>Atcayos</i> mutant mice by transverse aortic banding and found that absence of these lincRNAs did not affect cardiac hypertrophy or left ventricular function post-stress. Our results support roles for lincRNA transcripts and/or transcription to regulation of topologically associated genes. However, the individual importance of developmentally-specific lincRNAs is yet to be established. Their status as either gene-like entities or epigenetic components of the nucleus should be further considered." @default.
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- W2017088082 date "1972-02-26" @default.
- W2017088082 modified "2023-09-26" @default.
- W2017088082 title "Points from Letters: Puffs per Aerosol" @default.
- W2017088082 doi "https://doi.org/10.1136/bmj.1.5799.572-e" @default.
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